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- W2076987265 abstract "Plasma salicylate concentrations and the rates of total salicylate excretion in the urine were determined at the same time intervals after a single dose and also after multiple doses of aspirin B.P. and aloxiprin. In the single dose study appreciably higher plasma salicylate levels were obtained with the former, but very similar maximum rates of total salicylate excretion were obtained with both aspirin B.P. and aloxiprin. After aspirin B.P. the maximum plasma salicylate level occurred between one to two hours, but the maximum rate of total salicylate excretion occurred three or more hours after dosage. These results are explained by the accrual of metabolites and by a relatively lower rate of total metabolite formation at higher plasma salicylate levels. In the multiple dose study, a strong inverse relationship was observed between the body weight of an individual and the plasma salicylate concentration. Comparable plasma salicylate levels were obtained with aspirin B.P. and aloxiprin." @default.
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- W2076987265 title "Factors influencing the plasma salicylate concentration and urinary salicylate excretion after oral dosage with aspirin" @default.
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- W2076987265 doi "https://doi.org/10.1016/0006-2952(64)90013-9" @default.
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