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- W2076990015 abstract "Abstract Aureomycin was used in eighty-two surgical infections of the soft tissues which have been divided into the following groups: cellulitis, perirectal infections, peripheral ulcers, lymphadenitis, traumatic cases, gas gangrene infections and a miscellaneous group. Infections caused by a variety of grampositive and gram-negative bacilli were successfully treated. Most of these infections were caused by staphylococci or beta hemolytic streptococci. The miscellaneous group includes a case of bacteremia by the paracolon bacillus and one by S. minus. The age of the patients and medical complications have not hampered the activity of the drug. Aureomycin was used effectively by the oral, intramuscular and intravenous routes. Blood level studies and in vitro sensitivity tests have been performed and have confirmed the clinical results. No resistance to the drug has developed in any organism in cases in which prolonged administration was necessary. No serious clinical signs of toxicity have been seen as a result of drug administration. A chemical phlebitis developed in approximately 15 per cent of the patients receiving the drug intravenously if its administration extended two days or longer. In our hands aureomycin has yielded satisfactory results in the treatment of the reported infections whether used alone or as an adjunct to indicated surgery. It has appreciably shortened the clinical course of some infections, for example the lymphadenitis cases. In other infections such as cellulitis the usual rate of surgical intervention was markedly reduced during its use. In perirectal infections the use of the drug made early definitive surgery possible by reducing the local infection. Further use of aureomycin in the field of soft tissue infections seems definitely indicated." @default.
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- W2076990015 date "1950-02-01" @default.
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- W2076990015 title "Aureomycin in soft tissue infections" @default.
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- W2076990015 doi "https://doi.org/10.1016/0002-9610(50)90161-9" @default.
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