Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076990247> ?p ?o ?g. }
Showing items 1 to 60 of
60
with 100 items per page.
- W2076990247 endingPage "425" @default.
- W2076990247 startingPage "425" @default.
- W2076990247 abstract "This article describes an inquiry-based experiment for the undergraduate organic chemistry laboratory. The use of acetylides as nucleophiles is a common theme used in most organic textbooks as an introduction to retrosynthetic analysis. We have developed a problem-based application of this methodology for the first-semester organic laboratory. In this experiment, students are assigned to work in teams to design a microscale synthesis of an unsymmetrical alkyne using commercially available terminal alkynes and alkyl halides. Team members work collaboratively to perform the synthesis and characterize the resulting products using TLC, IR, and 1H NMR spectroscopy. Depending on the chosen reactants, students observe both substitution and elimination products, or in some cases, no reaction at all. Therefore, data interpretation is an important component of this experiment. Students must determine the composition of their product mixtures by comparison to starting materials. The structures of expected and unexpected products must be elucidated and justified mechanistically. Our students perform this experiment prior to the investigation of elimination reactions in the lecture, which adds a discovery element. This experiment can be performed in two three-hour lab periods; however, advance preparation is required for the synthetic design of an assigned target." @default.
- W2076990247 created "2016-06-24" @default.
- W2076990247 creator A5012033873 @default.
- W2076990247 creator A5014744019 @default.
- W2076990247 date "2006-03-01" @default.
- W2076990247 modified "2023-10-16" @default.
- W2076990247 title "Synthesis of Unsymmetrical Alkynes via the Alkylation of Sodium Acetylides. An Introduction to Synthetic Design for Organic Chemistry Students" @default.
- W2076990247 doi "https://doi.org/10.1021/ed083p425" @default.
- W2076990247 hasPublicationYear "2006" @default.
- W2076990247 type Work @default.
- W2076990247 sameAs 2076990247 @default.
- W2076990247 citedByCount "3" @default.
- W2076990247 countsByYear W20769902472015 @default.
- W2076990247 countsByYear W20769902472016 @default.
- W2076990247 crossrefType "journal-article" @default.
- W2076990247 hasAuthorship W2076990247A5012033873 @default.
- W2076990247 hasAuthorship W2076990247A5014744019 @default.
- W2076990247 hasConcept C161790260 @default.
- W2076990247 hasConcept C164361826 @default.
- W2076990247 hasConcept C178790620 @default.
- W2076990247 hasConcept C178907741 @default.
- W2076990247 hasConcept C185592680 @default.
- W2076990247 hasConcept C21951064 @default.
- W2076990247 hasConcept C2779012754 @default.
- W2076990247 hasConcept C2780263894 @default.
- W2076990247 hasConcept C35753019 @default.
- W2076990247 hasConcept C42437451 @default.
- W2076990247 hasConcept C535685238 @default.
- W2076990247 hasConceptScore W2076990247C161790260 @default.
- W2076990247 hasConceptScore W2076990247C164361826 @default.
- W2076990247 hasConceptScore W2076990247C178790620 @default.
- W2076990247 hasConceptScore W2076990247C178907741 @default.
- W2076990247 hasConceptScore W2076990247C185592680 @default.
- W2076990247 hasConceptScore W2076990247C21951064 @default.
- W2076990247 hasConceptScore W2076990247C2779012754 @default.
- W2076990247 hasConceptScore W2076990247C2780263894 @default.
- W2076990247 hasConceptScore W2076990247C35753019 @default.
- W2076990247 hasConceptScore W2076990247C42437451 @default.
- W2076990247 hasConceptScore W2076990247C535685238 @default.
- W2076990247 hasIssue "3" @default.
- W2076990247 hasLocation W20769902471 @default.
- W2076990247 hasOpenAccess W2076990247 @default.
- W2076990247 hasPrimaryLocation W20769902471 @default.
- W2076990247 hasRelatedWork W1999895594 @default.
- W2076990247 hasRelatedWork W2152558776 @default.
- W2076990247 hasRelatedWork W2506937901 @default.
- W2076990247 hasRelatedWork W2949772605 @default.
- W2076990247 hasRelatedWork W2950812624 @default.
- W2076990247 hasRelatedWork W4234098152 @default.
- W2076990247 hasRelatedWork W4379986989 @default.
- W2076990247 hasRelatedWork W4385784498 @default.
- W2076990247 hasRelatedWork W4386783933 @default.
- W2076990247 hasRelatedWork W2529650951 @default.
- W2076990247 hasVolume "83" @default.
- W2076990247 isParatext "false" @default.
- W2076990247 isRetracted "false" @default.
- W2076990247 magId "2076990247" @default.
- W2076990247 workType "article" @default.