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- W2076992016 abstract "Certain excitant drugs can enhance the effects of enriched experience on weights of brain sections and on the activities of acetylcholinesterase and cholinesterase in the brain, and certain depressants can lessen the brain weight effects. Most experiments were performed with prepubertal male rats. Some rats were exposed in groups of 12 to an enriched environmental condition (EC), usually for 2 h per day and over a 30-day period; others remained in their individual home cages (HC) throughout. Some received a drug injection and others received a saline injection before the daily EC period; HC controls received similar injections. The drug injections had no significant effects on brain values of HC rats, but they altered effects of EC, probably by influencing the animals' reactions to the environment. Methamphetamine and d-amphetamine enhanced the EC effects; metrazol had small positive effects, and strychnine was without effect. Phenobarbital depressed the brain weight effects but increased the enzymatic effects. Use of Methamphetamine made it possible to find EC effects with short daily periods (30 min) or with a shortened experimental duration (15 days). In experiments with adult rats, meth-amphetamine did not modulate the brain weight effects. The results of this study may bear on the use of stimulants to promote recovery from brain damage." @default.
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- W2076992016 title "Excitant and depressant drugs modulate effects of environment on brain weight and cholinesterases" @default.
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- W2076992016 doi "https://doi.org/10.1007/bf00437508" @default.
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