FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076993595> ?p ?o ?g. }

• W2076993595 endingPage "294" @default.
• W2076993595 startingPage "284" @default.
• W2076993595 abstract "In this study, we tested the androgenic activity of three structurally promising novel synthesized heterocyclic steroids compared with testosterone propionate in male mice. Additionally, the possible genotoxic effects of the novel synthesized heterocyclic steroids in comparison with testosterone propionate on male mice using chromosomal analysis of somatic and germ cells as well as RAPD-PCR were investigated. Male mice were administered with two doses of testosterone propionate, pyridoandrostene derivative 4b, pyrimidinoandrostene derivative 9a and thienoandrostene derivative 12 (200 and 400mg/kg b.w.) daily for 2 weeks. Results indicated that compounds 4b and 12 have androgenic activity as well as testosterone propionate. There were no significant differences in the frequencies of total chromosomal aberrations in both somatic and germ cells as well as no alteration in the DNA bands patterns between control, testosterone propionate and pyridoandrostene 4b treated animals. However, the pyrimidinoandrostene derivative 9a caused significant increase in the mean value of total chromosomal aberrations of both somatic and germ cells (P< or =0.01) as well as enhanced the polymorphic bands patterns as compared to the control and the other tested compounds. On the other hand, thienoandrostene derivative 12 induced significant decrease in the mean values of chromosomal aberrations in both somatic and germ cells, decreased sperm morphological abnormalities, increased the sperm count and motility than control. Our data indicate that testosterone propionate; pyridoandrostene 4b and thienoandrostene derivative 12 have no genotoxic activity. However, pyrimidinoandrostene derivative 9a has genotoxic activity possibly due to a modulation of the different expression of the catalyzing enzyme systems which will be investigated in the nearly future." @default.
• W2076993595 created "2016-06-24" @default.
• W2076993595 creator A5046409098 @default.
• W2076993595 creator A5058782797 @default.
• W2076993595 creator A5068272323 @default.
• W2076993595 creator A5080399689 @default.
• W2076993595 date "2008-06-01" @default.
• W2076993595 modified "2023-10-13" @default.
• W2076993595 title "Androgenic profile and genotoxicity evaluation of testosterone propionate and novel synthesized heterocyclic steroids" @default.
• W2076993595 cites W1642047822 @default.
• W2076993595 cites W1966863277 @default.
• W2076993595 cites W1977009097 @default.
• W2076993595 cites W1977512636 @default.
• W2076993595 cites W1979923292 @default.
• W2076993595 cites W1986401122 @default.
• W2076993595 cites W1986524478 @default.
• W2076993595 cites W1988965399 @default.
• W2076993595 cites W1992327518 @default.
• W2076993595 cites W2005781784 @default.
• W2076993595 cites W2006806278 @default.
• W2076993595 cites W2014442887 @default.
• W2076993595 cites W2021350807 @default.
• W2076993595 cites W2034607164 @default.
• W2076993595 cites W2036978149 @default.
• W2076993595 cites W2038310509 @default.
• W2076993595 cites W2054202669 @default.
• W2076993595 cites W2061002527 @default.
• W2076993595 cites W2080651245 @default.
• W2076993595 cites W2094139739 @default.
• W2076993595 cites W2100419911 @default.
• W2076993595 cites W2154166953 @default.
• W2076993595 cites W2155913334 @default.
• W2076993595 cites W2160471762 @default.
• W2076993595 cites W2166069155 @default.
• W2076993595 cites W2290002423 @default.
• W2076993595 cites W2323682321 @default.
• W2076993595 cites W2326289669 @default.
• W2076993595 cites W2335431241 @default.
• W2076993595 cites W4232635053 @default.
• W2076993595 doi "https://doi.org/10.1016/j.jsbmb.2007.11.006" @default.
• W2076993595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18513952" @default.
• W2076993595 hasPublicationYear "2008" @default.
• W2076993595 type Work @default.
• W2076993595 sameAs 2076993595 @default.
• W2076993595 citedByCount "26" @default.
• W2076993595 countsByYear W20769935952012 @default.
• W2076993595 countsByYear W20769935952013 @default.
• W2076993595 countsByYear W20769935952014 @default.
• W2076993595 countsByYear W20769935952015 @default.
• W2076993595 countsByYear W20769935952016 @default.
• W2076993595 countsByYear W20769935952017 @default.
• W2076993595 countsByYear W20769935952018 @default.
• W2076993595 countsByYear W20769935952020 @default.
• W2076993595 countsByYear W20769935952021 @default.
• W2076993595 countsByYear W20769935952022 @default.
• W2076993595 crossrefType "journal-article" @default.
• W2076993595 hasAuthorship W2076993595A5046409098 @default.
• W2076993595 hasAuthorship W2076993595A5058782797 @default.
• W2076993595 hasAuthorship W2076993595A5068272323 @default.
• W2076993595 hasAuthorship W2076993595A5080399689 @default.
• W2076993595 hasConcept C104317684 @default.
• W2076993595 hasConcept C126322002 @default.
• W2076993595 hasConcept C134018914 @default.
• W2076993595 hasConcept C134305767 @default.
• W2076993595 hasConcept C185592680 @default.
• W2076993595 hasConcept C2777911890 @default.
• W2076993595 hasConcept C2778959862 @default.
• W2076993595 hasConcept C2779279991 @default.
• W2076993595 hasConcept C2780014933 @default.
• W2076993595 hasConcept C2781087480 @default.
• W2076993595 hasConcept C2781115071 @default.
• W2076993595 hasConcept C29730261 @default.
• W2076993595 hasConcept C54355233 @default.
• W2076993595 hasConcept C55493867 @default.
• W2076993595 hasConcept C71315377 @default.
• W2076993595 hasConcept C71924100 @default.
• W2076993595 hasConcept C86803240 @default.
• W2076993595 hasConceptScore W2076993595C104317684 @default.
• W2076993595 hasConceptScore W2076993595C126322002 @default.
• W2076993595 hasConceptScore W2076993595C134018914 @default.
• W2076993595 hasConceptScore W2076993595C134305767 @default.
• W2076993595 hasConceptScore W2076993595C185592680 @default.
• W2076993595 hasConceptScore W2076993595C2777911890 @default.
• W2076993595 hasConceptScore W2076993595C2778959862 @default.
• W2076993595 hasConceptScore W2076993595C2779279991 @default.
• W2076993595 hasConceptScore W2076993595C2780014933 @default.
• W2076993595 hasConceptScore W2076993595C2781087480 @default.
• W2076993595 hasConceptScore W2076993595C2781115071 @default.
• W2076993595 hasConceptScore W2076993595C29730261 @default.
• W2076993595 hasConceptScore W2076993595C54355233 @default.
• W2076993595 hasConceptScore W2076993595C55493867 @default.
• W2076993595 hasConceptScore W2076993595C71315377 @default.
• W2076993595 hasConceptScore W2076993595C71924100 @default.
• W2076993595 hasConceptScore W2076993595C86803240 @default.
• W2076993595 hasIssue "3-5" @default.
• W2076993595 hasLocation W20769935951 @default.
• W2076993595 hasLocation W20769935952 @default.
• W2076993595 hasOpenAccess W2076993595 @default.

• next