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- W2076993889 endingPage "128" @default.
- W2076993889 startingPage "121" @default.
- W2076993889 abstract "Transforming growth factor-beta (TGF-beta) has been characterized as an injury-related factor, based on the observation that it is strongly up-regulated in many acute or chronic central nervous system disorders. TGF-beta is generally thought to be neuroprotective and several mechanisms have been proposed to explain this beneficial action. For instance, TGF-beta protects neurons against the potentiating effect of tissue-type plasminogen activator on NMDA receptor-mediated excitotoxicity, by up-regulating type-1 plasminogen activator inhibitor expression in astrocytes. TGF-beta has also anti-apoptotic properties, through a recruitment of a mitogen-activated protein kinase pathway and a concomitant activation of anti-apoptotic members of the Bcl-2 family. These multiple mechanisms might reflect the pleiotropic nature of TGF-beta, reinforcing the potential therapeutic value of this cytokine in several central nervous system disorders." @default.
- W2076993889 created "2016-06-24" @default.
- W2076993889 creator A5004749164 @default.
- W2076993889 creator A5015421764 @default.
- W2076993889 date "2006-02-01" @default.
- W2076993889 modified "2023-09-27" @default.
- W2076993889 title "Transforming growth factor-β signalling in brain disorders" @default.
- W2076993889 cites W1443476078 @default.
- W2076993889 cites W1494500191 @default.
- W2076993889 cites W1563615702 @default.
- W2076993889 cites W1586876258 @default.
- W2076993889 cites W1617304195 @default.
- W2076993889 cites W1777733877 @default.
- W2076993889 cites W1893974827 @default.
- W2076993889 cites W1914634699 @default.
- W2076993889 cites W1966180801 @default.
- W2076993889 cites W1969138341 @default.
- W2076993889 cites W1973531097 @default.
- W2076993889 cites W1974121861 @default.
- W2076993889 cites W1974502513 @default.
- W2076993889 cites W1978146894 @default.
- W2076993889 cites W1978161256 @default.
- W2076993889 cites W1979185206 @default.
- W2076993889 cites W1979549242 @default.
- W2076993889 cites W1979615699 @default.
- W2076993889 cites W1980523198 @default.
- W2076993889 cites W1980825018 @default.
- W2076993889 cites W1980920786 @default.
- W2076993889 cites W1982007787 @default.
- W2076993889 cites W1982196927 @default.
- W2076993889 cites W1984801123 @default.
- W2076993889 cites W1988567444 @default.
- W2076993889 cites W1991693875 @default.
- W2076993889 cites W1993593920 @default.
- W2076993889 cites W1993707025 @default.
- W2076993889 cites W2003907850 @default.
- W2076993889 cites W2006205771 @default.
- W2076993889 cites W2008079260 @default.
- W2076993889 cites W2011951446 @default.
- W2076993889 cites W2013662783 @default.
- W2076993889 cites W2016708365 @default.
- W2076993889 cites W2018454809 @default.
- W2076993889 cites W2023003439 @default.
- W2076993889 cites W2023184460 @default.
- W2076993889 cites W2023419933 @default.
- W2076993889 cites W2026394731 @default.
- W2076993889 cites W2027736619 @default.
- W2076993889 cites W2029401699 @default.
- W2076993889 cites W2029930927 @default.
- W2076993889 cites W2031588616 @default.
- W2076993889 cites W2031777569 @default.
- W2076993889 cites W2032968014 @default.
- W2076993889 cites W2034031602 @default.
- W2076993889 cites W2035653659 @default.
- W2076993889 cites W2035842921 @default.
- W2076993889 cites W2043725292 @default.
- W2076993889 cites W2045647567 @default.
- W2076993889 cites W2046411097 @default.
- W2076993889 cites W2047284199 @default.
- W2076993889 cites W2047406653 @default.
- W2076993889 cites W2047502947 @default.
- W2076993889 cites W2049243534 @default.
- W2076993889 cites W2049340271 @default.
- W2076993889 cites W2052313062 @default.
- W2076993889 cites W2053429985 @default.
- W2076993889 cites W2055861185 @default.
- W2076993889 cites W2055864323 @default.
- W2076993889 cites W2057067720 @default.
- W2076993889 cites W2058314672 @default.
- W2076993889 cites W2058698626 @default.
- W2076993889 cites W2058733924 @default.
- W2076993889 cites W2060663941 @default.
- W2076993889 cites W2061884534 @default.
- W2076993889 cites W2062952545 @default.
- W2076993889 cites W2064253775 @default.
- W2076993889 cites W2073396149 @default.
- W2076993889 cites W2075913912 @default.
- W2076993889 cites W2081030580 @default.
- W2076993889 cites W2086007941 @default.
- W2076993889 cites W2086180819 @default.
- W2076993889 cites W2087792631 @default.
- W2076993889 cites W2088735019 @default.
- W2076993889 cites W2089221634 @default.
- W2076993889 cites W2089383231 @default.
- W2076993889 cites W2090751897 @default.
- W2076993889 cites W2091551200 @default.
- W2076993889 cites W2092024431 @default.
- W2076993889 cites W2095067220 @default.
- W2076993889 cites W2098643301 @default.
- W2076993889 cites W2103745407 @default.
- W2076993889 cites W2107944268 @default.
- W2076993889 cites W2108085784 @default.
- W2076993889 cites W2114415876 @default.
- W2076993889 cites W2115379144 @default.
- W2076993889 cites W2122415594 @default.
- W2076993889 cites W2124135429 @default.
- W2076993889 cites W2129459566 @default.
- W2076993889 cites W2130524290 @default.