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- W2077013886 abstract "In a bacterial population, some cells stay single and motile, whereas others settle down and form chains. A study now investigates the mechanisms that determine these outcomes. See Article p.481 Genetically identical cells can make different cell-fate decisions in response to explicit extracellular triggers but also as a reaction to apparently stochastic or randomly generated stimuli arising within the cell. Is the underlying noise in gene expression a 'bug' or a key part of the cellular program? This study, a joint project from the labs of Richard Losick and Johan Paulsson, shows that chance has a role, at least for Bacillus subtilis bacteria. B. subtilis cells face a dramatic cell-fate decision, the transition between the solitary, motile state and the multicellular, chained state. The authors find that the bacterium switches from solitary to multicellular states according to a random, memoryless molecular mechanism, but that the underlying gene network is buffered against its own stochastic variations for the reverse transition. Thus bacteria keep track of time in order to force their progeny to cooperate with each other — a process that may inspire similarly quantitative research on development and cancer." @default.
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- W2077013886 date "2013-11-01" @default.
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- W2077013886 title "How bacteria choose a lifestyle" @default.
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- W2077013886 doi "https://doi.org/10.1038/nature12837" @default.
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