FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077018489> ?p ?o ?g. }

• W2077018489 endingPage "79" @default.
• W2077018489 startingPage "159" @default.
• W2077018489 abstract "The details of molecular switching points between apoptosis and autophagy in tumor cells have still not been fully elucidated. This study focused on the role of cathepsin B and its substrate, BID as molecular links between apoptosis and autophagy in human breast cancer MCF-7 cells exposed to camptothecin. Apoptosis occurred rapidly with a peak in 60 min after drug administration, whereas autophagy developed at a much slower rate with continuous progression during 24 h of cell exposure to the drug. CPT induced very rapid activation of cathepsin B. Inhibition of cathepsins by E64d prevented CPT-induced BAX and BID aggregation on mitochondria and reduced significantly reduced apoptotic cell number. The above effects were accompanied by an increase in autophagosome formation, measured by expression of MAP I LC3. BID knock down resulted in strong suppression of CPT-induced apoptosis and a shift of cell death towards autophagy, manifesting with an increase of Beclin 1 and MAP I LC3 cellular content." @default.
• W2077018489 created "2016-06-24" @default.
• W2077018489 creator A5005080403 @default.
• W2077018489 creator A5040696914 @default.
• W2077018489 creator A5049242399 @default.
• W2077018489 date "2005-06-01" @default.
• W2077018489 modified "2023-10-18" @default.
• W2077018489 title "Cathepsins and BID are involved in the molecular switch between apoptosis and autophagy in breast cancer MCF-7 cells exposed to camptothecin." @default.
• W2077018489 cites W161352313 @default.
• W2077018489 cites W1964198812 @default.
• W2077018489 cites W1977767269 @default.
• W2077018489 cites W1984145308 @default.
• W2077018489 cites W1993331127 @default.
• W2077018489 cites W2018692481 @default.
• W2077018489 cites W2019631673 @default.
• W2077018489 cites W2019922960 @default.
• W2077018489 cites W2023295105 @default.
• W2077018489 cites W2026589291 @default.
• W2077018489 cites W2028520206 @default.
• W2077018489 cites W2038302740 @default.
• W2077018489 cites W2061306124 @default.
• W2077018489 cites W2063403801 @default.
• W2077018489 cites W2064681912 @default.
• W2077018489 cites W2075796686 @default.
• W2077018489 cites W2087687780 @default.
• W2077018489 cites W2088580558 @default.
• W2077018489 cites W2090137644 @default.
• W2077018489 cites W2091483784 @default.
• W2077018489 cites W2100466458 @default.
• W2077018489 cites W2103782088 @default.
• W2077018489 cites W2109578505 @default.
• W2077018489 cites W2115742671 @default.
• W2077018489 cites W2129712803 @default.
• W2077018489 cites W2134388096 @default.
• W2077018489 cites W2142120946 @default.
• W2077018489 cites W2143358143 @default.
• W2077018489 cites W2149388384 @default.
• W2077018489 cites W2156320420 @default.
• W2077018489 cites W2318523475 @default.
• W2077018489 cites W2328267773 @default.
• W2077018489 cites W2407546618 @default.
• W2077018489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16077201" @default.
• W2077018489 hasPublicationYear "2005" @default.
• W2077018489 type Work @default.
• W2077018489 sameAs 2077018489 @default.
• W2077018489 citedByCount "22" @default.
• W2077018489 countsByYear W20770184892012 @default.
• W2077018489 countsByYear W20770184892013 @default.
• W2077018489 countsByYear W20770184892015 @default.
• W2077018489 countsByYear W20770184892017 @default.
• W2077018489 countsByYear W20770184892018 @default.
• W2077018489 countsByYear W20770184892019 @default.
• W2077018489 countsByYear W20770184892020 @default.
• W2077018489 countsByYear W20770184892022 @default.
• W2077018489 crossrefType "journal-article" @default.
• W2077018489 hasAuthorship W2077018489A5005080403 @default.
• W2077018489 hasAuthorship W2077018489A5040696914 @default.
• W2077018489 hasAuthorship W2077018489A5049242399 @default.
• W2077018489 hasConcept C109541995 @default.
• W2077018489 hasConcept C121608353 @default.
• W2077018489 hasConcept C167844969 @default.
• W2077018489 hasConcept C168296220 @default.
• W2077018489 hasConcept C173633252 @default.
• W2077018489 hasConcept C181199279 @default.
• W2077018489 hasConcept C185592680 @default.
• W2077018489 hasConcept C190283241 @default.
• W2077018489 hasConcept C203522944 @default.
• W2077018489 hasConcept C2779682216 @default.
• W2077018489 hasConcept C2780034444 @default.
• W2077018489 hasConcept C28021979 @default.
• W2077018489 hasConcept C2994423619 @default.
• W2077018489 hasConcept C31573885 @default.
• W2077018489 hasConcept C502942594 @default.
• W2077018489 hasConcept C54355233 @default.
• W2077018489 hasConcept C55493867 @default.
• W2077018489 hasConcept C86803240 @default.
• W2077018489 hasConcept C95444343 @default.
• W2077018489 hasConcept C96232424 @default.
• W2077018489 hasConceptScore W2077018489C109541995 @default.
• W2077018489 hasConceptScore W2077018489C121608353 @default.
• W2077018489 hasConceptScore W2077018489C167844969 @default.
• W2077018489 hasConceptScore W2077018489C168296220 @default.
• W2077018489 hasConceptScore W2077018489C173633252 @default.
• W2077018489 hasConceptScore W2077018489C181199279 @default.
• W2077018489 hasConceptScore W2077018489C185592680 @default.
• W2077018489 hasConceptScore W2077018489C190283241 @default.
• W2077018489 hasConceptScore W2077018489C203522944 @default.
• W2077018489 hasConceptScore W2077018489C2779682216 @default.
• W2077018489 hasConceptScore W2077018489C2780034444 @default.
• W2077018489 hasConceptScore W2077018489C28021979 @default.
• W2077018489 hasConceptScore W2077018489C2994423619 @default.
• W2077018489 hasConceptScore W2077018489C31573885 @default.
• W2077018489 hasConceptScore W2077018489C502942594 @default.
• W2077018489 hasConceptScore W2077018489C54355233 @default.
• W2077018489 hasConceptScore W2077018489C55493867 @default.
• W2077018489 hasConceptScore W2077018489C86803240 @default.
• W2077018489 hasConceptScore W2077018489C95444343 @default.
• W2077018489 hasConceptScore W2077018489C96232424 @default.

• next