FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077019257> ?p ?o ?g. }

• W2077019257 endingPage "2539" @default.
• W2077019257 startingPage "2531" @default.
• W2077019257 abstract "Objective. Our aim was to investigate effects of bosentan on hand perfusion in patients with systemic sclerosis (SSc) with pulmonary arterial hypertension (PAH), using laser Doppler perfusion imaging (LDPI). Methods. We enrolled 30 SSc patients with PAH, 30 SSc patients without PAH, and 30 healthy controls. In SSc patients and healthy controls at baseline, skin blood flow of the dorsum of the hands was determined with a Lisca laser Doppler perfusion imager. The dorsal surface of the hands was divided into 3 regions of interest (ROI). ROI 1 included 3 fingers of the hand from the second to the fourth distally to the proximal interphalangeal finger joint. ROI 2 included the area between the proximal interphalangeal and the metacarpophalangeal joint. ROI 3 included only the dorsal surface of the hand without the fingers. LDPI was repeated in SSc patients and controls after 4, 8, and 16 weeks of treatment. In SSc patients, nailfold videocapillaroscopy and Raynaud Condition Score (RCS) were performed at baseline and at 4, 8, and 16 weeks. Results. SSc patients with PAH enrolled in the study received treatment with bosentan as standard care for PAH. In these patients with PAH, after 8 and 16 weeks of treatment, bosentan improved minimum, mean, and maximum perfusion and the perfusion proximal-distal gradient. Bosentan seems to be most effective in patients with the early and active capillaroscopic pattern than in patients with the late pattern. Bosentan improved skin blood flow principally in the ROI 1 compared to the ROI 2 and ROI 3. Bosentan restored the perfusion proximal-distal gradient in 57% of SSc patients with the early capillaroscopic pattern. No significant differences from baseline were observed in the RCS in SSc patients with PAH. Conclusion. Bosentan improved skin perfusion in SSc patients with PAH, although it did not ameliorate symptoms of Raynaud’s phenomenon. Skin blood perfusion increased in SSc patients with PAH, particularly in the skin region distal to the proximal interphalangeal joint, and in patients with the early/active capillaroscopic pattern. Double-blind randomized clinical trials are needed to evaluate the effects of bosentan on skin perfusion of SSc patients without PAH and with active digital ulcers." @default.
• W2077019257 created "2016-06-24" @default.
• W2077019257 creator A5007808539 @default.
• W2077019257 creator A5012248416 @default.
• W2077019257 creator A5046799627 @default.
• W2077019257 creator A5047759238 @default.
• W2077019257 creator A5049064648 @default.
• W2077019257 creator A5081204631 @default.
• W2077019257 date "2010-09-01" @default.
• W2077019257 modified "2023-10-03" @default.
• W2077019257 title "Bosentan Improves Skin Perfusion of Hands in Patients with Systemic Sclerosis with Pulmonary Arterial Hypertension" @default.
• W2077019257 cites W1973638766 @default.
• W2077019257 cites W1993536085 @default.
• W2077019257 cites W1997716961 @default.
• W2077019257 cites W2010632029 @default.
• W2077019257 cites W2011355502 @default.
• W2077019257 cites W2018643804 @default.
• W2077019257 cites W2028921539 @default.
• W2077019257 cites W2029144162 @default.
• W2077019257 cites W2042411282 @default.
• W2077019257 cites W2054504088 @default.
• W2077019257 cites W2058500746 @default.
• W2077019257 cites W2070020982 @default.
• W2077019257 cites W2091944102 @default.
• W2077019257 cites W2099860929 @default.
• W2077019257 cites W2118846800 @default.
• W2077019257 cites W2118993128 @default.
• W2077019257 cites W2125171888 @default.
• W2077019257 cites W2132978366 @default.
• W2077019257 cites W2141863343 @default.
• W2077019257 cites W2154895287 @default.
• W2077019257 cites W2160183761 @default.
• W2077019257 cites W2164382299 @default.
• W2077019257 cites W74528526 @default.
• W2077019257 doi "https://doi.org/10.3899/jrheum.100358" @default.
• W2077019257 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20810512" @default.
• W2077019257 hasPublicationYear "2010" @default.
• W2077019257 type Work @default.
• W2077019257 sameAs 2077019257 @default.
• W2077019257 citedByCount "40" @default.
• W2077019257 countsByYear W20770192572012 @default.
• W2077019257 countsByYear W20770192572013 @default.
• W2077019257 countsByYear W20770192572014 @default.
• W2077019257 countsByYear W20770192572015 @default.
• W2077019257 countsByYear W20770192572016 @default.
• W2077019257 countsByYear W20770192572017 @default.
• W2077019257 countsByYear W20770192572018 @default.
• W2077019257 countsByYear W20770192572019 @default.
• W2077019257 countsByYear W20770192572020 @default.
• W2077019257 countsByYear W20770192572021 @default.
• W2077019257 countsByYear W20770192572022 @default.
• W2077019257 countsByYear W20770192572023 @default.
• W2077019257 crossrefType "journal-article" @default.
• W2077019257 hasAuthorship W2077019257A5007808539 @default.
• W2077019257 hasAuthorship W2077019257A5012248416 @default.
• W2077019257 hasAuthorship W2077019257A5046799627 @default.
• W2077019257 hasAuthorship W2077019257A5047759238 @default.
• W2077019257 hasAuthorship W2077019257A5049064648 @default.
• W2077019257 hasAuthorship W2077019257A5081204631 @default.
• W2077019257 hasBestOaLocation W20770192571 @default.
• W2077019257 hasConcept C105702510 @default.
• W2077019257 hasConcept C120770815 @default.
• W2077019257 hasConcept C126322002 @default.
• W2077019257 hasConcept C140530291 @default.
• W2077019257 hasConcept C141071460 @default.
• W2077019257 hasConcept C144980905 @default.
• W2077019257 hasConcept C146957229 @default.
• W2077019257 hasConcept C158846371 @default.
• W2077019257 hasConcept C164705383 @default.
• W2077019257 hasConcept C170493617 @default.
• W2077019257 hasConcept C2781109936 @default.
• W2077019257 hasConcept C2909338845 @default.
• W2077019257 hasConcept C2989005 @default.
• W2077019257 hasConcept C52305850 @default.
• W2077019257 hasConcept C71924100 @default.
• W2077019257 hasConceptScore W2077019257C105702510 @default.
• W2077019257 hasConceptScore W2077019257C120770815 @default.
• W2077019257 hasConceptScore W2077019257C126322002 @default.
• W2077019257 hasConceptScore W2077019257C140530291 @default.
• W2077019257 hasConceptScore W2077019257C141071460 @default.
• W2077019257 hasConceptScore W2077019257C144980905 @default.
• W2077019257 hasConceptScore W2077019257C146957229 @default.
• W2077019257 hasConceptScore W2077019257C158846371 @default.
• W2077019257 hasConceptScore W2077019257C164705383 @default.
• W2077019257 hasConceptScore W2077019257C170493617 @default.
• W2077019257 hasConceptScore W2077019257C2781109936 @default.
• W2077019257 hasConceptScore W2077019257C2909338845 @default.
• W2077019257 hasConceptScore W2077019257C2989005 @default.
• W2077019257 hasConceptScore W2077019257C52305850 @default.
• W2077019257 hasConceptScore W2077019257C71924100 @default.
• W2077019257 hasIssue "12" @default.
• W2077019257 hasLocation W20770192571 @default.
• W2077019257 hasLocation W20770192572 @default.
• W2077019257 hasOpenAccess W2077019257 @default.
• W2077019257 hasPrimaryLocation W20770192571 @default.
• W2077019257 hasRelatedWork W1906888141 @default.
• W2077019257 hasRelatedWork W1965882763 @default.
• W2077019257 hasRelatedWork W2058920408 @default.

• next