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- W2077020281 abstract "Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, ILHepatoma derived growth factor (HDGF) is a neurotrophic factor found in mouse spinal cord and hippocampal neurons. In various malignant tumors, the role of HDGF in tumor progression and its use as a diagnostic biomarker or therapeutic target have been extensively explored. However, the prognostic function and mitogenic role of HDGF in gliomagenesis is yet to be verified. In this study, we found a significant incidence of HDGF prevalence between the different pathological types and stages of glioma in 105 patients. We also found a prognostic significance in 41 glioblastoma multiforme (GBM) patients with the prevalence of nucleus HDGF predicts the short survival of GBM after surgery. To delineate the mitogenic role of HDGF in gliomagenesis, an adenoviral-expressed HDGF small interfering RNA (Ad-HDGF siRNA) was used to knock down the expression of nucleus HDGF. After knocking down the nuclear HDGF expression in human GBM cells, cell growth and cell invasion and induction on apoptosis by caspase-3 activation were significantly inhibited. We concluded that HDGF is a mitogenic growth factor in the progression of glioma and it can be a useful prognostic marker for GBM and therapeutic target for clinical management of glioma in the future.Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5627. doi:1538-7445.AM2012-5627" @default.
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- W2077020281 date "2012-04-15" @default.
- W2077020281 modified "2023-09-26" @default.
- W2077020281 title "Abstract 5627: Tumorigenesis and prognostic role of hepatoma-derived growth factor in human gliomas" @default.
- W2077020281 doi "https://doi.org/10.1158/1538-7445.am2012-5627" @default.
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