Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077028417> ?p ?o ?g. }
- W2077028417 endingPage "624" @default.
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- W2077028417 abstract "Abstract Ras genes are pre-eminent genes that are frequently linked with cancer biology. The functional loss of ras protein caused by various point mutations within the gene, is established as a prognostic factor for the genesis of a constitutively active Ras-MAPK pathway leading to cancer. Ras signaling circuit follows a complex pathway, which connects many signaling molecules and cells. Several strategies have come up for targeting mutant ras proteins for cancer therapy, however, the clinical benefits remain insignificant. Targeting the Ras-MAPK pathway is extremely complicated due its intricate networks involving several upstream and downstream regulators. Blocking oncogenic Ras is still in latent stage and requires alternative approaches to screen the genes involved in Ras transformation. Understanding the mechanism of Ras induced tumorigenesis in diverse cancers and signaling networks will open a path for drug development and other therapeutic approaches." @default.
- W2077028417 created "2016-06-24" @default.
- W2077028417 creator A5037501657 @default.
- W2077028417 creator A5074092867 @default.
- W2077028417 date "2013-04-23" @default.
- W2077028417 modified "2023-10-16" @default.
- W2077028417 title "Ras and Ras mutations in cancer" @default.
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