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- W2077033398 abstract "Opioid peptides are potent inhibitors of gastric somatostatin secretion. In the current investigation the effect of mu-opioid receptor blockade on responses to [D-Ala2,N-Me-Phe4,Gly5-ol]enkephalin (DAGO) was studied. Gastric inhibitory polypeptide (GIP; 1 nM) -stimulated secretion of immunoreactive somatostatin was almost completely inhibited by DAGO (1 microM). The mu-receptor antagonists, beta-funaltrexamine and naloxonazine, blocked the effect of DAGO. Pretreatment of rats with beta-funaltrexamine, 24 h prior to perfusion, reduced the percentage inhibition by DAGO from 88.6 +/- 5.2% to 50.7 +/- 9.3%. These studies support the involvement of mu-opioid inhibitory receptors in the regulation of gastric somatostatin secretion." @default.
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- W2077033398 date "1994-07-01" @default.
- W2077033398 modified "2023-09-26" @default.
- W2077033398 title "β-Funaltrexamine blockade of opioid-induced inhibition of somatostatin secretion from rat stomach" @default.
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- W2077033398 doi "https://doi.org/10.1016/0014-2999(94)90663-7" @default.
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