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- W2077040056 abstract "Diazepam (1), a hypnotic and anxiolytic drug in worldwide use, formed an intermediate product in a mixture of ethanol and sodium hydroxide ([NaOH] > or = 1 M). The intermediate product slowly decomposed to form 2-(methylamino)-5-chlorobenzophenone imine (2) and 2-(methylamino)-5-chlorobenzophenone (3). The amount of 2 formed, relative to that of 3, increased with increasing NaOH concentration. Compound 2, a heretofore unknown derivative of 1, was characterized by high-performance liquid chromatography, ultraviolet-visible absorption, mass, and proton nuclear magnetic resonance spectral analyses." @default.
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- W2077040056 date "1996-07-01" @default.
- W2077040056 modified "2023-10-16" @default.
- W2077040056 title "2-(Methylamino)-5-chlorobenzophenone Imine: A Novel Product Formed in Base-Catalyzed Hydrolysis of Diazepam" @default.
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- W2077040056 doi "https://doi.org/10.1021/js9504245" @default.
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