Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077056677> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2077056677 endingPage "260" @default.
- W2077056677 startingPage "253" @default.
- W2077056677 abstract "In order to demonstrate the effect to the acute administration of ethanol and chlorpromazine (CPZ) on bile flow and transhepatic transport of horseradish peroxidase (HRP) into bile, male rats were administered either 5 gm per kg ethanol intragastrically (E-rats) or 3 mg per kg CPZ intraperitoneally (CPZ rats). Control rats (C-rats) received saline. Two hours after ethanol feeding or 90 min after CPZ injection HRP was injected into the portal vein, and bile samples were collected at 1 0-min intervals for 2 hr. Tissue samples were removed at 1,10, 60, and 120 min to study HRP transport using electron microscopic cytochemical localization. Bile flow was reduced (p < 0.001) both in E- and CPZ-rats compared to C-rats. In E-rats HRP secretion was significantly decreased at 30 and 40 min post-HRP injection (p < 0.05) and the peak rate of HRP secretion was delayed by 10 min compared to C-rats. Uptake and transhepatic transport of HRP were similar to controls. These results suggest that bile secretion and flow were impaired by ethanol. CPZ inhibited secretion of HRP significantly (p < 0.001) during the first hr after HRP injection and by 25% after 2 hr. In CPZ rats studied cytochemically HRP reaction product decreased in the cytoplasm of hepatocytes 10 min after HRP injection (p < 0.01). These findings suggest that acute CPZ administration caused an inhibition of the uptake of HRP as well as secretion and bile flow." @default.
- W2077056677 created "2016-06-24" @default.
- W2077056677 creator A5000630075 @default.
- W2077056677 creator A5013972611 @default.
- W2077056677 creator A5017078328 @default.
- W2077056677 creator A5085764453 @default.
- W2077056677 date "1984-03-01" @default.
- W2077056677 modified "2023-09-27" @default.
- W2077056677 title "Effect of Ethanol and Chlorpromazine on Transhepatic Transport and Biliary Secretion of Horseradish Peroxidase" @default.
- W2077056677 cites W1486814308 @default.
- W2077056677 cites W1619447324 @default.
- W2077056677 cites W1858519155 @default.
- W2077056677 cites W1905780384 @default.
- W2077056677 cites W1928191868 @default.
- W2077056677 cites W1948530997 @default.
- W2077056677 cites W1982630366 @default.
- W2077056677 cites W1987282769 @default.
- W2077056677 cites W1990259332 @default.
- W2077056677 cites W1999546336 @default.
- W2077056677 cites W2006387884 @default.
- W2077056677 cites W2011191028 @default.
- W2077056677 cites W2018034388 @default.
- W2077056677 cites W2024276064 @default.
- W2077056677 cites W2044166627 @default.
- W2077056677 cites W2051020426 @default.
- W2077056677 cites W2055839793 @default.
- W2077056677 cites W2074381499 @default.
- W2077056677 cites W2076651840 @default.
- W2077056677 cites W2082784116 @default.
- W2077056677 cites W2088935018 @default.
- W2077056677 cites W2091079066 @default.
- W2077056677 cites W2091726464 @default.
- W2077056677 cites W2091951407 @default.
- W2077056677 cites W2111278472 @default.
- W2077056677 cites W2114758077 @default.
- W2077056677 cites W2127112840 @default.
- W2077056677 cites W2141376249 @default.
- W2077056677 cites W2212482596 @default.
- W2077056677 cites W2354203206 @default.
- W2077056677 cites W417033224 @default.
- W2077056677 cites W69613843 @default.
- W2077056677 cites W7908460 @default.
- W2077056677 doi "https://doi.org/10.1002/hep.1840040214" @default.
- W2077056677 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6706299" @default.
- W2077056677 hasPublicationYear "1984" @default.
- W2077056677 type Work @default.
- W2077056677 sameAs 2077056677 @default.
- W2077056677 citedByCount "22" @default.
- W2077056677 crossrefType "journal-article" @default.
- W2077056677 hasAuthorship W2077056677A5000630075 @default.
- W2077056677 hasAuthorship W2077056677A5013972611 @default.
- W2077056677 hasAuthorship W2077056677A5017078328 @default.
- W2077056677 hasAuthorship W2077056677A5085764453 @default.
- W2077056677 hasBestOaLocation W20770566771 @default.
- W2077056677 hasConcept C126322002 @default.
- W2077056677 hasConcept C134018914 @default.
- W2077056677 hasConcept C181199279 @default.
- W2077056677 hasConcept C185592680 @default.
- W2077056677 hasConcept C2777397205 @default.
- W2077056677 hasConcept C2777676563 @default.
- W2077056677 hasConcept C2780161600 @default.
- W2077056677 hasConcept C49039625 @default.
- W2077056677 hasConcept C55493867 @default.
- W2077056677 hasConcept C71924100 @default.
- W2077056677 hasConceptScore W2077056677C126322002 @default.
- W2077056677 hasConceptScore W2077056677C134018914 @default.
- W2077056677 hasConceptScore W2077056677C181199279 @default.
- W2077056677 hasConceptScore W2077056677C185592680 @default.
- W2077056677 hasConceptScore W2077056677C2777397205 @default.
- W2077056677 hasConceptScore W2077056677C2777676563 @default.
- W2077056677 hasConceptScore W2077056677C2780161600 @default.
- W2077056677 hasConceptScore W2077056677C49039625 @default.
- W2077056677 hasConceptScore W2077056677C55493867 @default.
- W2077056677 hasConceptScore W2077056677C71924100 @default.
- W2077056677 hasIssue "2" @default.
- W2077056677 hasLocation W20770566771 @default.
- W2077056677 hasLocation W20770566772 @default.
- W2077056677 hasOpenAccess W2077056677 @default.
- W2077056677 hasPrimaryLocation W20770566771 @default.
- W2077056677 hasRelatedWork W1966296538 @default.
- W2077056677 hasRelatedWork W2009877402 @default.
- W2077056677 hasRelatedWork W2020884724 @default.
- W2077056677 hasRelatedWork W2054119993 @default.
- W2077056677 hasRelatedWork W2056503472 @default.
- W2077056677 hasRelatedWork W2071934027 @default.
- W2077056677 hasRelatedWork W2074268135 @default.
- W2077056677 hasRelatedWork W2090408064 @default.
- W2077056677 hasRelatedWork W2161296685 @default.
- W2077056677 hasRelatedWork W4255681344 @default.
- W2077056677 hasVolume "4" @default.
- W2077056677 isParatext "false" @default.
- W2077056677 isRetracted "false" @default.
- W2077056677 magId "2077056677" @default.
- W2077056677 workType "article" @default.