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- W2077061870 abstract "The mouse Tcr locus is defined by its central role in the transmission ratio distortion phenotype characteristic of t haplotypes. A molecular candidate for Tcr has been identified in the form of a gene—Tcp-10b—expressed during spermatogenesis. Tcp-10b is one member of a multigene family present in two to four copies on different homologs of chromosome 17. The coding regions of the Tcp-10 genes present within two inbred strains were compared with those of the tω5 haplotype. The various gene family members are highly conserved relative to each other with a minimum nucleotide identity of 98.6% in all pairwise comparisons. Maximal parsimony analysis indicates that the Tcp-10 gene family has evolved in a concerted manner with the obliteration of nearly all individual gene-specific characteristics. As a consequence, the candidate for the fulllength mutant Tcr gene product is distinguished by only a single, highly conservative, amino acid change. The data are consistent with the hypothesis that the effector of mutant Tcr activity is a second, alternatively spliced product that is expressed in a haploid- and allele-specific manner." @default.
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- W2077061870 date "1992-01-01" @default.
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- W2077061870 title "Concerted evolution of the mouse Tcp-10 gene family: Implications for the functional basis of t haplotype transmission ratio distortion" @default.
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- W2077061870 doi "https://doi.org/10.1016/0888-7543(92)90403-f" @default.
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