Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077065310> ?p ?o ?g. }
- W2077065310 abstract "Progranulin is a newly discovered 88-kDa glycoprotein originally purified from the highly tumorigenic mouse teratoma-derived cell line PC. We found that high progranulin expression was associated with higher breast carcinoma angiogenesis, reflected by increased vascular endothelial growth factor expression and higher microvessel density. However, no immunohistochemical evidence currently exists to correlate progranulin expression with clinicopathological features in different intrinsic subtypes of breast carcinoma biopsies. The aim of this study was to investigate the progranulin expression profiles in the intrinsic subtypes of breast carcinomas and their relevance to histopathological and clinicopathological features. Tissue blocks containing 264 cases of breast carcinomas from 2006 to 2009 were classified as different intrinsic subtypes. Tissues of four intrinsic subtypes were immunostained for progranulin, vascular endothelial growth factor and CD105. Their relevance to histopathological and clinicopathological features was also analyzed. Twenty tissue samples from breast fibroadenomas were included in this study. Progranulin expression showed no significant differences in different intrinsic subtypes, although an increasing tendency could be found in the triple-negative breast cancer (TNBC) subgroup (χ(2)=5.00, df=3, p=0.17). However, differences were significant when pathologically node metastasis-positive (pN(+)) TNBC were excluded (χ(2)=17.84, df=3, p<0.01). Some clinicopathological parameters, including CK5/6 (χ(2)=0.08, df=3, p=0.78), E-cadherin (χ(2)=0.71, df=3, p=0.40) and P53 (χ(2)=0.05, df=3, p=0.83), displayed no correlation with activity of progranulin in pathologically node metastasis-negative (pN(-)) TNBC. It was noted that the EGFR expression level of the pN(-) TNBC subtype was significantly higher in cases with strong progranulin expression than in cases with weak progranulin expression (χ(2)=11.26, df=1, p<0.01). A significantly higher expression level of progranulin in pN(-) TNBC suggests that progranulin is a promising new target for pN(-) TNBC treatment. Strong expression of progranulin correlates with positive EGFR expression in the pN(-) TNBC subtype. The close relationship between EGFR and progranulin/VEGF/CD105 expression may partly play a role in high angiogenesis levels in the pN(-) TNBC subtype." @default.
- W2077065310 created "2016-06-24" @default.
- W2077065310 creator A5032703676 @default.
- W2077065310 creator A5039007950 @default.
- W2077065310 creator A5044809170 @default.
- W2077065310 creator A5050371463 @default.
- W2077065310 creator A5055880436 @default.
- W2077065310 creator A5078088700 @default.
- W2077065310 date "2012-04-01" @default.
- W2077065310 modified "2023-09-27" @default.
- W2077065310 title "Progranulin expression in breast cancer with different intrinsic subtypes" @default.
- W2077065310 cites W1973599157 @default.
- W2077065310 cites W1978150117 @default.
- W2077065310 cites W1997576290 @default.
- W2077065310 cites W2015413901 @default.
- W2077065310 cites W2035570331 @default.
- W2077065310 cites W2039680999 @default.
- W2077065310 cites W2040839197 @default.
- W2077065310 cites W2044182531 @default.
- W2077065310 cites W2055396864 @default.
- W2077065310 cites W2064241564 @default.
- W2077065310 cites W2095973840 @default.
- W2077065310 cites W2097255042 @default.
- W2077065310 cites W2104638648 @default.
- W2077065310 cites W2105456592 @default.
- W2077065310 cites W2123129045 @default.
- W2077065310 cites W2126275851 @default.
- W2077065310 cites W2127057139 @default.
- W2077065310 cites W2130900820 @default.
- W2077065310 cites W2136655134 @default.
- W2077065310 cites W2137853125 @default.
- W2077065310 cites W2138474420 @default.
- W2077065310 cites W2138929540 @default.
- W2077065310 cites W2143336748 @default.
- W2077065310 cites W2157285286 @default.
- W2077065310 cites W2161426850 @default.
- W2077065310 cites W2170602872 @default.
- W2077065310 cites W2271587842 @default.
- W2077065310 cites W2313296912 @default.
- W2077065310 doi "https://doi.org/10.1016/j.prp.2012.02.001" @default.
- W2077065310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22397762" @default.
- W2077065310 hasPublicationYear "2012" @default.
- W2077065310 type Work @default.
- W2077065310 sameAs 2077065310 @default.
- W2077065310 citedByCount "15" @default.
- W2077065310 countsByYear W20770653102013 @default.
- W2077065310 countsByYear W20770653102014 @default.
- W2077065310 countsByYear W20770653102016 @default.
- W2077065310 countsByYear W20770653102017 @default.
- W2077065310 countsByYear W20770653102018 @default.
- W2077065310 countsByYear W20770653102019 @default.
- W2077065310 countsByYear W20770653102021 @default.
- W2077065310 countsByYear W20770653102022 @default.
- W2077065310 crossrefType "journal-article" @default.
- W2077065310 hasAuthorship W2077065310A5032703676 @default.
- W2077065310 hasAuthorship W2077065310A5039007950 @default.
- W2077065310 hasAuthorship W2077065310A5044809170 @default.
- W2077065310 hasAuthorship W2077065310A5050371463 @default.
- W2077065310 hasAuthorship W2077065310A5055880436 @default.
- W2077065310 hasAuthorship W2077065310A5078088700 @default.
- W2077065310 hasConcept C10205521 @default.
- W2077065310 hasConcept C121608353 @default.
- W2077065310 hasConcept C126322002 @default.
- W2077065310 hasConcept C142724271 @default.
- W2077065310 hasConcept C204232928 @default.
- W2077065310 hasConcept C2776524808 @default.
- W2077065310 hasConcept C2777546739 @default.
- W2077065310 hasConcept C2779013556 @default.
- W2077065310 hasConcept C2780110267 @default.
- W2077065310 hasConcept C2780394083 @default.
- W2077065310 hasConcept C28328180 @default.
- W2077065310 hasConcept C2910866450 @default.
- W2077065310 hasConcept C3018521938 @default.
- W2077065310 hasConcept C502942594 @default.
- W2077065310 hasConcept C530470458 @default.
- W2077065310 hasConcept C54355233 @default.
- W2077065310 hasConcept C6061869 @default.
- W2077065310 hasConcept C63363279 @default.
- W2077065310 hasConcept C71924100 @default.
- W2077065310 hasConcept C86803240 @default.
- W2077065310 hasConceptScore W2077065310C10205521 @default.
- W2077065310 hasConceptScore W2077065310C121608353 @default.
- W2077065310 hasConceptScore W2077065310C126322002 @default.
- W2077065310 hasConceptScore W2077065310C142724271 @default.
- W2077065310 hasConceptScore W2077065310C204232928 @default.
- W2077065310 hasConceptScore W2077065310C2776524808 @default.
- W2077065310 hasConceptScore W2077065310C2777546739 @default.
- W2077065310 hasConceptScore W2077065310C2779013556 @default.
- W2077065310 hasConceptScore W2077065310C2780110267 @default.
- W2077065310 hasConceptScore W2077065310C2780394083 @default.
- W2077065310 hasConceptScore W2077065310C28328180 @default.
- W2077065310 hasConceptScore W2077065310C2910866450 @default.
- W2077065310 hasConceptScore W2077065310C3018521938 @default.
- W2077065310 hasConceptScore W2077065310C502942594 @default.
- W2077065310 hasConceptScore W2077065310C530470458 @default.
- W2077065310 hasConceptScore W2077065310C54355233 @default.
- W2077065310 hasConceptScore W2077065310C6061869 @default.
- W2077065310 hasConceptScore W2077065310C63363279 @default.
- W2077065310 hasConceptScore W2077065310C71924100 @default.
- W2077065310 hasConceptScore W2077065310C86803240 @default.