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- W2077065674 abstract "A series of cyano- and carboxyborane adducts of cyclohexylamines and toluidines were shown to be cytotoxic towards suspended single cell tumors. The carboxyborane adducts of cyclohexylamine were more potent than the cyanoborane adducts of cyclohexylamine or any of the toluidine derivatives. A number of the compounds were active at 8 mg/kg/day i.p. in the Ehrlich ascites carcinoma screen in vivo. The mode of action study with N-methylcyclohexylaminecyanoborane 10 in L-1210 lymphoid leukemia cells showed that RNA synthesis was markedly reduced followed by DNA synthesis. Purine de novo synthesis was suppressed at PRPP-amido transferase, IMP dehydrogenase, and dihydrofolate reductase enzyme sites. The agent also interfered with DNA template activity causing reduction of DNA polymerase alpha, and RNA polymerase I, II and III activities. The d[NTP] pools were marginally reduced while DNA viscosity was reduced and DNA fragmentation occurred." @default.
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- W2077065674 date "2010-08-12" @default.
- W2077065674 modified "2023-09-27" @default.
- W2077065674 title "ChemInform Abstract: Synthesis and Cytotoxicity of Amine-Borane Adducts of Cyclohexylamines and Toluidines." @default.
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- W2077065674 doi "https://doi.org/10.1002/chin.199614187" @default.
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