Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077066483> ?p ?o ?g. }
- W2077066483 endingPage "300" @default.
- W2077066483 startingPage "292" @default.
- W2077066483 abstract "To test the association between psychosocial factors and circulating levels of matrix metalloproteinase-9 (MMP-9) in a normal population sample. Psychosocial factors have been associated with inflammatory markers and are of prognostic significance for coronary artery disease (CAD). The degrading enzyme MMP-9 is upregulated in inflammatory processes and hypothesized to play a role in the rupture of atherosclerotic plaques.A total of 402 participants (50% women), aged 45 to 69 years, were drawn randomly from a normal population. Psychosocial instruments covered depression (Center for Epidemiological Studies Depression Questionnaire, CES-D), vital exhaustion, hostile affect, cynicism, mastery, self-esteem, sense of coherence (SOC), emotional support, and social integration. Plasma MMP-9 was measured by an enzyme-linked immunosorbent assay method. Linear regression models were adjusted for age, sex, known CAD, rheumatoid arthritis, cancer, cardiovascular risk factors including C-reactive protein and ongoing medication.After full adjustment, there were independent associations of elevated MMP-9 levels with CES-D (+2.9 ng/ml per SD, p = .02), hostile affect (+3.0 ng/ml per SD, p = .02), cynicism (+3.5 ng/ml per SD, p = .006), and SOC (-2.5 ng/ml per SD, p = .046). A principal component analysis extracted three components. The first was mainly extracted from CES-D, vital exhaustion, self-esteem, mastery, and SOC; the second was mainly extracted from hostile affect and cynicism. Both were independently associated with MMP-9 (p = .02, p = .04) when run in the same model.MMP-9 levels were associated with psychosocial factors in a middle-aged normal population sample, independently of traditional risk factors. The findings may constitute a possible link between psychosocial factors and cardiovascular risk." @default.
- W2077066483 created "2016-06-24" @default.
- W2077066483 creator A5000715414 @default.
- W2077066483 creator A5021288139 @default.
- W2077066483 creator A5063292170 @default.
- W2077066483 creator A5083437719 @default.
- W2077066483 creator A5089557260 @default.
- W2077066483 date "2009-04-01" @default.
- W2077066483 modified "2023-09-25" @default.
- W2077066483 title "Plasma Levels of Matrix Metalloproteinase-9 are Independently Associated With Psychosocial Factors in a Middle-Aged Normal Population" @default.
- W2077066483 cites W19446086 @default.
- W2077066483 cites W1975202701 @default.
- W2077066483 cites W1981466881 @default.
- W2077066483 cites W1982143048 @default.
- W2077066483 cites W1983446823 @default.
- W2077066483 cites W1984323465 @default.
- W2077066483 cites W1984742880 @default.
- W2077066483 cites W1992834760 @default.
- W2077066483 cites W1995645776 @default.
- W2077066483 cites W1995823861 @default.
- W2077066483 cites W2002771508 @default.
- W2077066483 cites W2009978724 @default.
- W2077066483 cites W2018563944 @default.
- W2077066483 cites W2019400588 @default.
- W2077066483 cites W2019995128 @default.
- W2077066483 cites W2020866554 @default.
- W2077066483 cites W2020982843 @default.
- W2077066483 cites W2022941966 @default.
- W2077066483 cites W2028304868 @default.
- W2077066483 cites W2037647232 @default.
- W2077066483 cites W2038168708 @default.
- W2077066483 cites W2044920762 @default.
- W2077066483 cites W2045742923 @default.
- W2077066483 cites W2050290821 @default.
- W2077066483 cites W2051118203 @default.
- W2077066483 cites W2053670331 @default.
- W2077066483 cites W2058312082 @default.
- W2077066483 cites W2062975122 @default.
- W2077066483 cites W2064190260 @default.
- W2077066483 cites W2065579783 @default.
- W2077066483 cites W2067038967 @default.
- W2077066483 cites W2069574950 @default.
- W2077066483 cites W2072249256 @default.
- W2077066483 cites W2088023626 @default.
- W2077066483 cites W2088158101 @default.
- W2077066483 cites W2094941678 @default.
- W2077066483 cites W2101075322 @default.
- W2077066483 cites W2106319388 @default.
- W2077066483 cites W2106834148 @default.
- W2077066483 cites W2107284231 @default.
- W2077066483 cites W2112778345 @default.
- W2077066483 cites W2116404316 @default.
- W2077066483 cites W2122450058 @default.
- W2077066483 cites W2122810132 @default.
- W2077066483 cites W2123994513 @default.
- W2077066483 cites W2124267928 @default.
- W2077066483 cites W2129214570 @default.
- W2077066483 cites W2134410622 @default.
- W2077066483 cites W2137842351 @default.
- W2077066483 cites W2138150045 @default.
- W2077066483 cites W2144716474 @default.
- W2077066483 cites W2144741700 @default.
- W2077066483 cites W2149464773 @default.
- W2077066483 cites W2153458404 @default.
- W2077066483 cites W2155121555 @default.
- W2077066483 cites W2157858034 @default.
- W2077066483 cites W2163857054 @default.
- W2077066483 cites W2168595038 @default.
- W2077066483 cites W2168699761 @default.
- W2077066483 cites W2184483218 @default.
- W2077066483 cites W2324841714 @default.
- W2077066483 cites W2325727313 @default.
- W2077066483 cites W4230026896 @default.
- W2077066483 cites W4256402462 @default.
- W2077066483 cites W91600810 @default.
- W2077066483 doi "https://doi.org/10.1097/psy.0b013e3181960e7f" @default.
- W2077066483 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19196809" @default.
- W2077066483 hasPublicationYear "2009" @default.
- W2077066483 type Work @default.
- W2077066483 sameAs 2077066483 @default.
- W2077066483 citedByCount "44" @default.
- W2077066483 countsByYear W20770664832012 @default.
- W2077066483 countsByYear W20770664832013 @default.
- W2077066483 countsByYear W20770664832014 @default.
- W2077066483 countsByYear W20770664832015 @default.
- W2077066483 countsByYear W20770664832016 @default.
- W2077066483 countsByYear W20770664832017 @default.
- W2077066483 countsByYear W20770664832018 @default.
- W2077066483 countsByYear W20770664832019 @default.
- W2077066483 countsByYear W20770664832021 @default.
- W2077066483 countsByYear W20770664832023 @default.
- W2077066483 crossrefType "journal-article" @default.
- W2077066483 hasAuthorship W2077066483A5000715414 @default.
- W2077066483 hasAuthorship W2077066483A5021288139 @default.
- W2077066483 hasAuthorship W2077066483A5063292170 @default.
- W2077066483 hasAuthorship W2077066483A5083437719 @default.
- W2077066483 hasAuthorship W2077066483A5089557260 @default.
- W2077066483 hasBestOaLocation W20770664832 @default.