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• W2077070865 startingPage "e0121455" @default.
• W2077070865 abstract "Viruses interact with various permissive and restrictive factors in host cells throughout their replication cycle. Cell lines that are non-permissive to viral infection have been particularly useful in discovering host cell proteins involved in viral life cycles. Here we describe the characterization of a human myeloid leukemia cell line, KG-1, that is resistant to infection by retroviruses and a Rhabdovirus. We show that KG-1 cells are resistant to infection by Vesicular Stomatits Virus as well as VSV Glycoprotein (VSVG) pseudotyped retroviruses due to a defect in binding. Moreover our results indicate that entry by xenotropic retroviral envelope glycoprotein RD114 is impaired in KG-1 cells. Finally we characterize a post- entry block in the early phase of the retroviral life cycle in KG-1 cells that renders the cell line refractory to infection. This cell line will have utility in discovering proteins involved in infection by VSV and HIV-1." @default.
• W2077070865 created "2016-06-24" @default.
• W2077070865 creator A5007594180 @default.
• W2077070865 creator A5048173987 @default.
• W2077070865 date "2015-03-26" @default.
• W2077070865 modified "2023-09-23" @default.
• W2077070865 title "Characterization of Resistance to Rhabdovirus and Retrovirus Infection in a Human Myeloid Cell Line" @default.
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• W2077070865 doi "https://doi.org/10.1371/journal.pone.0121455" @default.
• W2077070865 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4374779" @default.
• W2077070865 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25811758" @default.
• W2077070865 hasPublicationYear "2015" @default.
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