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• W2077072108 abstract "Despite the well-described attention and short-term memory enhancing effects of H3 receptor antagonists, and evidence to suggest a close relationship between central histaminergic and cholinergic systems, there is a paucity of evidence for a role for H3 receptor blockade in spatial learning. To address this, we investigated two H3 receptor antagonists in a visual discrimination water maze in rats, and in a Barnes circular maze in mice. Thioperamide and ciproxifan significantly attenuated a scopolamine-induced deficit in the water maze task, while only ciproxifan showed a modest attenuation in the Barnes maze. Taken together, these data suggest a role for H3 receptors in spatial learning that appears to be task-dependent." @default.
• W2077072108 created "2016-06-24" @default.
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• W2077072108 date "2005-04-01" @default.
• W2077072108 modified "2023-10-14" @default.
• W2077072108 title "Effects of histamine H3 receptor antagonists in two models of spatial learning" @default.
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• W2077072108 doi "https://doi.org/10.1016/j.bbr.2004.11.008" @default.
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