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- W2077079354 abstract "Abstract Mice were exchange transfused with a fluorocarbon emulsion (FC-80). Their hematocrits were reduced to levels of 10–15. The survival time of these animals was significantly longer than that of control mice transfused with dextrose-saline, or saline alone, provided they were kept on 100% O2. Survival was related to the capacity of FC-80 blood, over a wide range of HCT, to carry larger amounts of oxygen than did normal blood, provided both bloods were drawn from mice breathing 100% O2. Fluorescein transit time through the cerebral microcirculation was normal or slightly accelerated in the majority of FC-80 mice. Acceleration may have been due to reduced “blood” viscosity. A relationship was found between microcirculatory viability as judged by transit time, and the continued capacity of the brain to respond to anoxia with a rise in NADH. Thus all mice with normal or reduced transit times displayed reversible increases in brain NADH levels when they were rendered anoxic while a small group of mice with prolonged fluorescein transit, tended to display NADH levels which failed to rise when O2 was reduced in the inspired air. Many FC-80 mice displayed reversible decreases in brain PO2 levels when inspired O2 was reduced. Pentylenetetrazol activated the EEG of FC-80 mice. The EEG activity was reversibly reduced when the animals were briefly exposed to room air or N2. These data suggest that fluorocarbon emulsions can support brain microcirculation, oxygenation and electrical activity in vivo, a result which is consonant with the observations of others who have performed in vitro experiments, or observed long-term survival." @default.
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- W2077079354 date "1974-05-01" @default.
- W2077079354 modified "2023-09-25" @default.
- W2077079354 title "Fluorocarbon emulsion as a blood substitute: Cerebral microcirculation and related parameters" @default.
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- W2077079354 doi "https://doi.org/10.1016/0026-2862(74)90018-1" @default.
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