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- W2077080163 abstract "UK-114 is a 14-kDa ubiquitous protein recently sequenced by several groups throughout the world. Its activity ranges from being a tumor antigen, a protein synthesis inhibitor or a specific mu-calpain activator. UK-114 shows structural homologies also with proteins of the MHC-1 binding proteins, and heat shock proteins (HSPs). We investigated the possible effects of UK-114 on T helper cells cytokine profile and the development and progression of experimental autoimmune diseases. Homogeneous recombinant UK-114 was used in all experiments. Treatment of Balb/c male mice for two weeks resulted in the increase of IL-4, and the decrease of TNF-alpha, IFN-gamma, and IL-2 release from stimulated splenocytes, suggesting that UK-114 modulates the Th1/Th2 cytokine profile toward Th2. Similar to that observed with HSP60/65, a single pretreatment of Lewis rats with UK-114 significantly blunted the development of adjuvant-induced arthritis, whereas chronic treatment of 4-week-old female NOD mice dose dependently inhibited the development of diabetes." @default.
- W2077080163 created "2016-06-24" @default.
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- W2077080163 date "1999-06-01" @default.
- W2077080163 modified "2023-09-26" @default.
- W2077080163 title "Chronic Administration of UK-114, a Multifunctional Emerging Protein, Modulates the Th1/Th2 Cytokine Pattern and Experimental Autoimmune Diseases" @default.
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- W2077080163 doi "https://doi.org/10.1111/j.1749-6632.1999.tb07643.x" @default.
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