Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077082214> ?p ?o ?g. }
- W2077082214 abstract "Abstract Background Bacterial meningitis caused by Streptococcus pneumonia e leads to death in up to 30% of patients and leaves up to half of the survivors with neurological sequelae. The inflammatory host reaction initiates the induction of the kynurenine pathway and contributes to hippocampal apoptosis, a form of brain damage that is associated with learning and memory deficits in experimental paradigms. Vitamin B6 is an enzymatic cofactor in the kynurenine pathway and may thus limit the accumulation of neurotoxic metabolites and preserve the cellular energy status. The aim of this study in a pneumococcal meningitis model was to investigate the effect of vitamin B6 on hippocampal apoptosis by histomorphology, by transcriptomics and by measurement of cellular nicotine amide adenine dinucleotide content. Methods and results Eleven day old Wistar rats were infected with 1x10 6 cfu/ml of S . pneumoniae and randomized for treatment with vitamin B6 or saline as controls. Vitamin B6 led to a significant (p > 0.02) reduction of hippocampal apoptosis. According to functional annotation based clustering, vitamin B6 led to down-regulation of genes involved in processes of inflammatory response, while genes encoding for processes related to circadian rhythm, neuronal signaling and apoptotic cell death were mostly up-regulated. Conclusions Our results provide evidence that attenuation of apoptosis by vitamin B6 is multi-factorial including down-modulation of inflammation, up-regulation of the neuroprotective brain-derived neurotrophic factor and prevention of the exhaustion of cellular energy stores. The neuroprotective effect identifies vitamin B6 as a potential target for the development of strategies to attenuate brain injury in bacterial meningitis." @default.
- W2077082214 created "2016-06-24" @default.
- W2077082214 creator A5020647499 @default.
- W2077082214 creator A5021171892 @default.
- W2077082214 creator A5022896497 @default.
- W2077082214 creator A5067266133 @default.
- W2077082214 date "2013-08-27" @default.
- W2077082214 modified "2023-10-07" @default.
- W2077082214 title "Vitamin B6 reduces hippocampal apoptosis in experimental pneumococcal meningitis" @default.
- W2077082214 cites W1482276319 @default.
- W2077082214 cites W1538666979 @default.
- W2077082214 cites W1582132479 @default.
- W2077082214 cites W1592192663 @default.
- W2077082214 cites W1636107121 @default.
- W2077082214 cites W1663629741 @default.
- W2077082214 cites W1920308054 @default.
- W2077082214 cites W1968890500 @default.
- W2077082214 cites W1970512911 @default.
- W2077082214 cites W1973668096 @default.
- W2077082214 cites W1974786258 @default.
- W2077082214 cites W1979910707 @default.
- W2077082214 cites W1982204342 @default.
- W2077082214 cites W1986071925 @default.
- W2077082214 cites W1987932370 @default.
- W2077082214 cites W1991082974 @default.
- W2077082214 cites W1991599421 @default.
- W2077082214 cites W1994349595 @default.
- W2077082214 cites W2006886561 @default.
- W2077082214 cites W2012099989 @default.
- W2077082214 cites W2013583124 @default.
- W2077082214 cites W2021643429 @default.
- W2077082214 cites W2023015070 @default.
- W2077082214 cites W2032444015 @default.
- W2077082214 cites W2034506209 @default.
- W2077082214 cites W2034816834 @default.
- W2077082214 cites W2040226877 @default.
- W2077082214 cites W2040429518 @default.
- W2077082214 cites W2053806684 @default.
- W2077082214 cites W2058731742 @default.
- W2077082214 cites W2058986447 @default.
- W2077082214 cites W2061353658 @default.
- W2077082214 cites W2064475864 @default.
- W2077082214 cites W2067500000 @default.
- W2077082214 cites W2069399682 @default.
- W2077082214 cites W2071683156 @default.
- W2077082214 cites W2072049799 @default.
- W2077082214 cites W2076928103 @default.
- W2077082214 cites W2090260132 @default.
- W2077082214 cites W2092564896 @default.
- W2077082214 cites W2095290902 @default.
- W2077082214 cites W2096825172 @default.
- W2077082214 cites W2100243763 @default.
- W2077082214 cites W2113119852 @default.
- W2077082214 cites W2113853601 @default.
- W2077082214 cites W2115995125 @default.
- W2077082214 cites W2116634113 @default.
- W2077082214 cites W2120331990 @default.
- W2077082214 cites W2124368930 @default.
- W2077082214 cites W2133470211 @default.
- W2077082214 cites W2145016852 @default.
- W2077082214 cites W2145025818 @default.
- W2077082214 cites W2146962006 @default.
- W2077082214 cites W2147388199 @default.
- W2077082214 cites W2150854367 @default.
- W2077082214 cites W2153718589 @default.
- W2077082214 cites W2160697532 @default.
- W2077082214 cites W2160700740 @default.
- W2077082214 cites W2161601115 @default.
- W2077082214 cites W2161683931 @default.
- W2077082214 cites W2163844879 @default.
- W2077082214 cites W2166588400 @default.
- W2077082214 cites W2169860818 @default.
- W2077082214 cites W2172293806 @default.
- W2077082214 cites W4294216483 @default.
- W2077082214 doi "https://doi.org/10.1186/1471-2334-13-393" @default.
- W2077082214 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3765858" @default.
- W2077082214 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23977941" @default.
- W2077082214 hasPublicationYear "2013" @default.
- W2077082214 type Work @default.
- W2077082214 sameAs 2077082214 @default.
- W2077082214 citedByCount "21" @default.
- W2077082214 countsByYear W20770822142014 @default.
- W2077082214 countsByYear W20770822142015 @default.
- W2077082214 countsByYear W20770822142016 @default.
- W2077082214 countsByYear W20770822142017 @default.
- W2077082214 countsByYear W20770822142018 @default.
- W2077082214 countsByYear W20770822142019 @default.
- W2077082214 countsByYear W20770822142020 @default.
- W2077082214 countsByYear W20770822142021 @default.
- W2077082214 countsByYear W20770822142022 @default.
- W2077082214 countsByYear W20770822142023 @default.
- W2077082214 crossrefType "journal-article" @default.
- W2077082214 hasAuthorship W2077082214A5020647499 @default.
- W2077082214 hasAuthorship W2077082214A5021171892 @default.
- W2077082214 hasAuthorship W2077082214A5022896497 @default.
- W2077082214 hasAuthorship W2077082214A5067266133 @default.
- W2077082214 hasBestOaLocation W20770822141 @default.
- W2077082214 hasConcept C126322002 @default.
- W2077082214 hasConcept C141071460 @default.
- W2077082214 hasConcept C160539049 @default.