FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077084518> ?p ?o ?g. }

• W2077084518 endingPage "405" @default.
• W2077084518 startingPage "395" @default.
• W2077084518 abstract "Background DNA triplexes are higher-order nucleic acid structures with potential roles in gene regulation and hence biochemical and therapeutic applications. The stabilizing influence exerted by water molecules on the conformation of the DNA duplex is well known. However, the role of water molecules in the DNA triple helix has not been investigated. We have previously determined the solution structures of the purine·purine·pyrimidine (R·RY) and pyrimidine·purine·pyrimidine (Y·RY) structural motifs in DNA triplexes and identified both the global helical parameters, as well as local helical distortions associated with non-standard base triple pairing alignments.Results Here we have used homonuclear two-dimensional NMR spectroscopy to define the hydration sites in R·RY and Y·RY DNA triplexes in aqueous solution. Long-lived hydration sites with residence times exceeding 1 nanosecond have been identified in the new groove formed by the Hoogsteen paired strands in both triplexes. Distinctive patterns of hydration are displayed by each triplex in the remaining two grooves.Conclusions The role played by water molecules in DNA triplexes appears to be similar to that played in duplexes. By binding to specific sites, particularly in the narrow groove formed by the Hoogsteen paired strands whose phosphate groups are in close proximity, water molecules may stabilize the triplex by shielding it against unfavorable electrostatic interactions." @default.
• W2077084518 created "2016-06-24" @default.
• W2077084518 creator A5022552567 @default.
• W2077084518 creator A5077706769 @default.
• W2077084518 date "1994-05-01" @default.
• W2077084518 modified "2023-10-10" @default.
• W2077084518 title "Hydration sites in purine·purine·pyrimidine and pyrimidine·purine·pyrimidine DNA triplexes in aqueous solution" @default.
• W2077084518 cites W1577332561 @default.
• W2077084518 cites W1795473064 @default.
• W2077084518 cites W1967021794 @default.
• W2077084518 cites W1968360065 @default.
• W2077084518 cites W1971188879 @default.
• W2077084518 cites W1978883716 @default.
• W2077084518 cites W1992043136 @default.
• W2077084518 cites W2000184211 @default.
• W2077084518 cites W2004059420 @default.
• W2077084518 cites W2018617236 @default.
• W2077084518 cites W2019296317 @default.
• W2077084518 cites W2019388715 @default.
• W2077084518 cites W2023990202 @default.
• W2077084518 cites W2024574250 @default.
• W2077084518 cites W2026689869 @default.
• W2077084518 cites W2038540983 @default.
• W2077084518 cites W2052333294 @default.
• W2077084518 cites W2053018494 @default.
• W2077084518 cites W2055069311 @default.
• W2077084518 cites W2062326564 @default.
• W2077084518 cites W2064248870 @default.
• W2077084518 cites W2066180422 @default.
• W2077084518 cites W2069298274 @default.
• W2077084518 cites W2072551399 @default.
• W2077084518 cites W2082589966 @default.
• W2077084518 cites W2083009384 @default.
• W2077084518 cites W2091643064 @default.
• W2077084518 cites W2093347837 @default.
• W2077084518 cites W2106315897 @default.
• W2077084518 cites W2106858736 @default.
• W2077084518 cites W2124582467 @default.
• W2077084518 cites W2132373675 @default.
• W2077084518 cites W2133918133 @default.
• W2077084518 cites W2137723211 @default.
• W2077084518 cites W2149114131 @default.
• W2077084518 cites W2177205004 @default.
• W2077084518 cites W4251663802 @default.
• W2077084518 doi "https://doi.org/10.1016/s0969-2126(00)00041-1" @default.
• W2077084518 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8081755" @default.
• W2077084518 hasPublicationYear "1994" @default.
• W2077084518 type Work @default.
• W2077084518 sameAs 2077084518 @default.
• W2077084518 citedByCount "26" @default.
• W2077084518 crossrefType "journal-article" @default.
• W2077084518 hasAuthorship W2077084518A5022552567 @default.
• W2077084518 hasAuthorship W2077084518A5077706769 @default.
• W2077084518 hasConcept C10919887 @default.
• W2077084518 hasConcept C178790620 @default.
• W2077084518 hasConcept C181199279 @default.
• W2077084518 hasConcept C185592680 @default.
• W2077084518 hasConcept C2776476023 @default.
• W2077084518 hasConcept C2779321679 @default.
• W2077084518 hasConcept C32909587 @default.
• W2077084518 hasConcept C552990157 @default.
• W2077084518 hasConcept C55493867 @default.
• W2077084518 hasConcept C61234307 @default.
• W2077084518 hasConcept C71240020 @default.
• W2077084518 hasConcept C8010536 @default.
• W2077084518 hasConceptScore W2077084518C10919887 @default.
• W2077084518 hasConceptScore W2077084518C178790620 @default.
• W2077084518 hasConceptScore W2077084518C181199279 @default.
• W2077084518 hasConceptScore W2077084518C185592680 @default.
• W2077084518 hasConceptScore W2077084518C2776476023 @default.
• W2077084518 hasConceptScore W2077084518C2779321679 @default.
• W2077084518 hasConceptScore W2077084518C32909587 @default.
• W2077084518 hasConceptScore W2077084518C552990157 @default.
• W2077084518 hasConceptScore W2077084518C55493867 @default.
• W2077084518 hasConceptScore W2077084518C61234307 @default.
• W2077084518 hasConceptScore W2077084518C71240020 @default.
• W2077084518 hasConceptScore W2077084518C8010536 @default.
• W2077084518 hasIssue "5" @default.
• W2077084518 hasLocation W20770845181 @default.
• W2077084518 hasLocation W20770845182 @default.
• W2077084518 hasOpenAccess W2077084518 @default.
• W2077084518 hasPrimaryLocation W20770845181 @default.
• W2077084518 hasRelatedWork W1981246559 @default.
• W2077084518 hasRelatedWork W2008962778 @default.
• W2077084518 hasRelatedWork W2024631851 @default.
• W2077084518 hasRelatedWork W2026493142 @default.
• W2077084518 hasRelatedWork W2066419609 @default.
• W2077084518 hasRelatedWork W2092635513 @default.
• W2077084518 hasRelatedWork W2097008541 @default.
• W2077084518 hasRelatedWork W2950383430 @default.
• W2077084518 hasRelatedWork W2950417274 @default.
• W2077084518 hasRelatedWork W3190613683 @default.
• W2077084518 hasVolume "2" @default.
• W2077084518 isParatext "false" @default.
• W2077084518 isRetracted "false" @default.
• W2077084518 magId "2077084518" @default.
• W2077084518 workType "article" @default.