FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077087310> ?p ?o ?g. }

• W2077087310 endingPage "160" @default.
• W2077087310 startingPage "151" @default.
• W2077087310 abstract "Objectives: To investigate differences in liver enzyme elevation (LEE) between HIV-infected patients with and without HCV coinfection who start a darunavir/ritonavir-containing regimen. Methods: HIV-infected patients enrolled in the Italian Cohort of Naïve to Antiretrovirals (ICONA) Foundation Study were included if they started darunavir/ritonavir for the first time. Patients were classified as not HCV coinfected, HCV active coinfected (HCV RNA positive), and HCV nonactive coinfected (HCV-Ab positive/HCV RNA negative). Time to LEE endpoint was defined using the ACTG toxicity scale, based on changes relative to baseline. Kaplan-Meier was used to estimate 1-year and 2-year probability of LEE. The incidence rate ratios (IRRs) of LEEs were estimated until the last follow-up (intention-to-treat analysis [ITT]) and up to darunavir/ritonavir discontinuation (on-treatment analysis [OT]). Results: Overall, 703 patients were included. Ninety-one were HCV-Ab positive; of those, 68 (9.7%) had active HCV coinfection. In 879 person-years of follow-up, 101 LEEs occurred (ITT). No severe hepatotoxicity event was registered in active HCV coinfected patients. HCV active coinfection was predictive of LEE in the overall population (OT: adjusted incidence rate ratio (IRR), 2.25; 95% CI, 0.70–7.24; P = .17; ITT: adjusted IRR, 3.62; 95% CI, 1.67–7.83; P .001) and in naïve patients (OT: adjusted IRR, 6.29; 95% CI, 2.54–15.55; P = .00; ITT: adjusted IRR, 3.87; 95% CI, 0.99–15.16; P = .05). Conclusions: No grade 3–4 LEEs occurred in HCV active coinfected patients. HCV active coinfected patients experienced low grade LEEs more frequently than HCV-Ab negative patients. Darunavir/ritonavir seems to be safe whatever the HCV status, when liver enzymes are carefully monitored." @default.
• W2077087310 created "2016-06-24" @default.
• W2077087310 creator A5002495981 @default.
• W2077087310 creator A5010288279 @default.
• W2077087310 creator A5017885138 @default.
• W2077087310 creator A5032359240 @default.
• W2077087310 creator A5047438814 @default.
• W2077087310 creator A5058024552 @default.
• W2077087310 creator A5064623739 @default.
• W2077087310 creator A5064631193 @default.
• W2077087310 creator A5066933191 @default.
• W2077087310 creator A5078701955 @default.
• W2077087310 creator A5082122622 @default.
• W2077087310 creator A5090207334 @default.
• W2077087310 date "2014-08-01" @default.
• W2077087310 modified "2023-10-06" @default.
• W2077087310 title "Liver Enzyme Elevation During Darunavir-Based Antiretroviral Treatment in HIV-1–Infected Patients With or Without Hepatitis C Coinfection: Data from the ICONA Foundation Cohort" @default.
• W2077087310 cites W114538374 @default.
• W2077087310 cites W1967347018 @default.
• W2077087310 cites W1970513035 @default.
• W2077087310 cites W1986859702 @default.
• W2077087310 cites W1987974009 @default.
• W2077087310 cites W1996311973 @default.
• W2077087310 cites W2008258552 @default.
• W2077087310 cites W2014370035 @default.
• W2077087310 cites W2015754190 @default.
• W2077087310 cites W2026930921 @default.
• W2077087310 cites W2034482023 @default.
• W2077087310 cites W2038686418 @default.
• W2077087310 cites W2043781839 @default.
• W2077087310 cites W2044570337 @default.
• W2077087310 cites W2045840367 @default.
• W2077087310 cites W2049969210 @default.
• W2077087310 cites W2058615508 @default.
• W2077087310 cites W2068781014 @default.
• W2077087310 cites W2071684418 @default.
• W2077087310 cites W2076339980 @default.
• W2077087310 cites W2085691878 @default.
• W2077087310 cites W2086808262 @default.
• W2077087310 cites W2090157578 @default.
• W2077087310 cites W2134413729 @default.
• W2077087310 cites W2141776019 @default.
• W2077087310 cites W2142434090 @default.
• W2077087310 cites W2147577150 @default.
• W2077087310 cites W2164007491 @default.
• W2077087310 doi "https://doi.org/10.1310/hct1504-151" @default.
• W2077087310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25143024" @default.
• W2077087310 hasPublicationYear "2014" @default.
• W2077087310 type Work @default.
• W2077087310 sameAs 2077087310 @default.
• W2077087310 citedByCount "9" @default.
• W2077087310 countsByYear W20770873102015 @default.
• W2077087310 countsByYear W20770873102016 @default.
• W2077087310 countsByYear W20770873102017 @default.
• W2077087310 countsByYear W20770873102018 @default.
• W2077087310 countsByYear W20770873102019 @default.
• W2077087310 countsByYear W20770873102020 @default.
• W2077087310 countsByYear W20770873102021 @default.
• W2077087310 crossrefType "journal-article" @default.
• W2077087310 hasAuthorship W2077087310A5002495981 @default.
• W2077087310 hasAuthorship W2077087310A5010288279 @default.
• W2077087310 hasAuthorship W2077087310A5017885138 @default.
• W2077087310 hasAuthorship W2077087310A5032359240 @default.
• W2077087310 hasAuthorship W2077087310A5047438814 @default.
• W2077087310 hasAuthorship W2077087310A5058024552 @default.
• W2077087310 hasAuthorship W2077087310A5064623739 @default.
• W2077087310 hasAuthorship W2077087310A5064631193 @default.
• W2077087310 hasAuthorship W2077087310A5066933191 @default.
• W2077087310 hasAuthorship W2077087310A5078701955 @default.
• W2077087310 hasAuthorship W2077087310A5082122622 @default.
• W2077087310 hasAuthorship W2077087310A5090207334 @default.
• W2077087310 hasConcept C120665830 @default.
• W2077087310 hasConcept C121332964 @default.
• W2077087310 hasConcept C126322002 @default.
• W2077087310 hasConcept C142462285 @default.
• W2077087310 hasConcept C203014093 @default.
• W2077087310 hasConcept C2522874641 @default.
• W2077087310 hasConcept C2776408679 @default.
• W2077087310 hasConcept C2776455275 @default.
• W2077087310 hasConcept C2777813720 @default.
• W2077087310 hasConcept C2778715236 @default.
• W2077087310 hasConcept C2779182219 @default.
• W2077087310 hasConcept C2779298103 @default.
• W2077087310 hasConcept C2781413609 @default.
• W2077087310 hasConcept C2908647359 @default.
• W2077087310 hasConcept C2993143319 @default.
• W2077087310 hasConcept C3013748606 @default.
• W2077087310 hasConcept C61511704 @default.
• W2077087310 hasConcept C71924100 @default.
• W2077087310 hasConcept C72563966 @default.
• W2077087310 hasConcept C90924648 @default.
• W2077087310 hasConcept C99454951 @default.
• W2077087310 hasConceptScore W2077087310C120665830 @default.
• W2077087310 hasConceptScore W2077087310C121332964 @default.
• W2077087310 hasConceptScore W2077087310C126322002 @default.
• W2077087310 hasConceptScore W2077087310C142462285 @default.
• W2077087310 hasConceptScore W2077087310C203014093 @default.
• W2077087310 hasConceptScore W2077087310C2522874641 @default.

• next