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- W2077097103 abstract "Down-regulation and recovery of endothelin (ET) receptors and of ET-dependent phosphoinositide-specific phospholipase C (PI-PLC) signaling was examined in cultured cardiomyocytes from neonatal rats. Three hours treatment with 5 nM ET-1 decreased surface receptors to 30%, and transduction to 19%, of their respective time-zero values. After extensive washing and a 3 h recovery period surface receptors returned to 74% of the time-zero value, with concomitant recovery of signal transduction to 75% of the time-zero value. The recovery of PI-PLC signaling in these cells is in contrast with a previous report, but consistent with recovery of the receptor complement." @default.
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- W2077097103 date "2001-11-01" @default.
- W2077097103 modified "2023-09-27" @default.
- W2077097103 title "Down-Regulation and Recovery of Endothelin-1 Binding and Signaling in Rat Cardiomyocytes" @default.
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- W2077097103 doi "https://doi.org/10.1006/bbrc.2001.5812" @default.
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