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• W2077098077 abstract "The purpose of this study was to apply the attractive technique of the microwaves irradiation (MW) for the preparation of solvent-free solid dispersions (SD). In particular, the microwave technology has been considered in order to prepare an enhanced release dosage form for the poorly soluble drug Ibuprofen (IBU), employing PVP/VA 60/40 (PVP/VA 64) and hydroxypropyl-beta-cyclodextrin (HP-beta-CD) as hydrophilic carriers. Their physico-chemical characteristics and dissolution properties were compared to the corresponding physical mixtures and the drug alone. The results of physico-chemical characterization attested a correspondence of the solid state of the drug before and after irradiation treatment and that an amorphous form of the drug was obtained. This result, together with the presence of the hydrophilic polymers determined a remarkable enhancement of the in vitro dissolution rate of the drug suggesting that the microwave technique could be considered as a new and interesting method to prepare drug-polymer systems." @default.
• W2077098077 created "2016-06-24" @default.
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• W2077098077 date "2008-09-01" @default.
• W2077098077 modified "2023-09-24" @default.
• W2077098077 title "Microwave generated solid dispersions containing Ibuprofen" @default.
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• W2077098077 doi "https://doi.org/10.1016/j.ijpharm.2008.05.026" @default.
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