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- W2077098295 abstract "protein expression and subcellular localization with prognosis. METHODS: Tissues microarray from 136 intracapsular clear cell RCC cases were constructed and two anti-pVHL Ab (Ig32 and Ig33) and a polyclonal anti-HIF-1 Ab were used for IHC analysis. Mean follow up was 117 months. It was performed mutational analysis for the whole VHL and for HIF-1 SNP (C1772T), promoter methylation of VHL and LOH (3p25). The results were correlated with survival (TSS). RESULTS: VHL gene alteration was found in 57% of cases. VHL mutations, methylation and LOH were detected in 51%, 11% and 17% cases. Patients with biallelic VHL alteration had a shorter TSS (p=0.01). We found a statistical association between biallelic VHL alteration and no pVHL expression (p=0.004) and nuclear localization of HIF-1 (p=0,04). The SNP was associated only with a cytoplasmic localization of HIF-1 (p=0.007). pVHL negativity and HIF-1 nuclear positivity were correlated with a short TSS. CONCLUSIONS: VHL and HIF-1 alterations influence their protein expression and localization. Biallelic VHL gene alterations with loss of pVHL expression are associated to nuclear localization of HIF1-a and poor prognosis in early-stage clear cell RCC. Alteration of pVHL/HIF1 pathway is an early event in clear cell RCC carcinogenesis and it is involved in cancer progression through nuclear localizzation of HIF-1 ." @default.
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- W2077098295 date "2009-04-01" @default.
- W2077098295 modified "2023-10-13" @default.
- W2077098295 title "THE PROGNOSIC IMPORTANCE OF ANGIOGENIC PHENOTYPE IN RENAL CELL CARCINOMA" @default.
- W2077098295 doi "https://doi.org/10.1016/s0022-5347(09)60318-9" @default.
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