Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077107039> ?p ?o ?g. }
- W2077107039 endingPage "e74966" @default.
- W2077107039 startingPage "e74966" @default.
- W2077107039 abstract "Amyloid-β (Aβ) plays a causative role in Alzheimer's disease. Apolipoprotein E (apoE) is involved in Aβ accumulation, whereas occlusal disharmony increases Aβ production in the rat hippocampus. The purpose of the present study was to investigate the effects of apoE deficiency and occlusal disharmony on Aβ production and spatial memory. Wild-type (WT) (n = 12) and apoE-deficient [ApoE(-/-)] (n = 12) rats (Sprague-Dawley; 8 weeks old) were used. These rats were randomly divided into four groups of six rats each: two control (C) groups: WT (C-WT) and ApoE [C-ApoE(-/-)], and two occlusal disharmony (D) groups: WT (D-WT) and ApoE [D-ApoE(-/-)]. The C group received no treatment for 8 weeks. In the D group, the maxillary molar cusps were cut off for 8 weeks. The spatial memory of rats was assessed according to their behavioral performance in a radial arm maze. In both genotypes of rats, significant differences in the reference memory, Aβ42 production, β-secretase expression and plasma corticosterone levels were observed between the C and D groups (P < 0.0125). The levels of Aβ42 and glucocorticoid receptor in the C-ApoE(-/-) group were also significantly higher than those in the C-WT group (P < 0.0125). However, no significant differences in these parameters were found between the two genotypes with occlusal disharmony. In conclusion, occlusal disharmony induces cognitive dysfunction and Aβ accumulation in the rat hippocampus, and the effects of occlusal disharmony on Aβ accumulation and cognitive dysfunction were larger than those of apoE deficiency." @default.
- W2077107039 created "2016-06-24" @default.
- W2077107039 creator A5011143226 @default.
- W2077107039 creator A5021230448 @default.
- W2077107039 creator A5030844021 @default.
- W2077107039 creator A5040110076 @default.
- W2077107039 creator A5042021885 @default.
- W2077107039 creator A5061595379 @default.
- W2077107039 creator A5087348549 @default.
- W2077107039 date "2013-09-16" @default.
- W2077107039 modified "2023-10-16" @default.
- W2077107039 title "Effects of apoE Deficiency and Occlusal Disharmony on Amyloid-Beta Production and Spatial Memory in Rats" @default.
- W2077107039 cites W1528171054 @default.
- W2077107039 cites W1966975077 @default.
- W2077107039 cites W1971043719 @default.
- W2077107039 cites W1977086524 @default.
- W2077107039 cites W1985137206 @default.
- W2077107039 cites W1985329800 @default.
- W2077107039 cites W1991200283 @default.
- W2077107039 cites W1992032787 @default.
- W2077107039 cites W1993356262 @default.
- W2077107039 cites W1997822484 @default.
- W2077107039 cites W2001688761 @default.
- W2077107039 cites W2002558640 @default.
- W2077107039 cites W2004906992 @default.
- W2077107039 cites W2009050065 @default.
- W2077107039 cites W2015859225 @default.
- W2077107039 cites W2018898693 @default.
- W2077107039 cites W2020877938 @default.
- W2077107039 cites W2021181758 @default.
- W2077107039 cites W2021333248 @default.
- W2077107039 cites W2025994696 @default.
- W2077107039 cites W2028674750 @default.
- W2077107039 cites W2029497425 @default.
- W2077107039 cites W2031353556 @default.
- W2077107039 cites W2032602280 @default.
- W2077107039 cites W2034968148 @default.
- W2077107039 cites W2036362108 @default.
- W2077107039 cites W2038759284 @default.
- W2077107039 cites W2040939766 @default.
- W2077107039 cites W2043012963 @default.
- W2077107039 cites W2045284949 @default.
- W2077107039 cites W2054007740 @default.
- W2077107039 cites W2054975950 @default.
- W2077107039 cites W2071134351 @default.
- W2077107039 cites W2072682191 @default.
- W2077107039 cites W2080146582 @default.
- W2077107039 cites W2089202441 @default.
- W2077107039 cites W2092292312 @default.
- W2077107039 cites W2095745901 @default.
- W2077107039 cites W2096396734 @default.
- W2077107039 cites W2097608504 @default.
- W2077107039 cites W2103440561 @default.
- W2077107039 cites W2106067304 @default.
- W2077107039 cites W2109666614 @default.
- W2077107039 cites W2111113314 @default.
- W2077107039 cites W2128565374 @default.
- W2077107039 cites W2133887339 @default.
- W2077107039 cites W2143955562 @default.
- W2077107039 cites W2145450560 @default.
- W2077107039 cites W2161002325 @default.
- W2077107039 cites W2164642027 @default.
- W2077107039 cites W2167541367 @default.
- W2077107039 cites W2313212133 @default.
- W2077107039 cites W2316785311 @default.
- W2077107039 cites W32481776 @default.
- W2077107039 doi "https://doi.org/10.1371/journal.pone.0074966" @default.
- W2077107039 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3774813" @default.
- W2077107039 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24066161" @default.
- W2077107039 hasPublicationYear "2013" @default.
- W2077107039 type Work @default.
- W2077107039 sameAs 2077107039 @default.
- W2077107039 citedByCount "11" @default.
- W2077107039 countsByYear W20771070392014 @default.
- W2077107039 countsByYear W20771070392015 @default.
- W2077107039 countsByYear W20771070392016 @default.
- W2077107039 countsByYear W20771070392019 @default.
- W2077107039 countsByYear W20771070392021 @default.
- W2077107039 countsByYear W20771070392022 @default.
- W2077107039 crossrefType "journal-article" @default.
- W2077107039 hasAuthorship W2077107039A5011143226 @default.
- W2077107039 hasAuthorship W2077107039A5021230448 @default.
- W2077107039 hasAuthorship W2077107039A5030844021 @default.
- W2077107039 hasAuthorship W2077107039A5040110076 @default.
- W2077107039 hasAuthorship W2077107039A5042021885 @default.
- W2077107039 hasAuthorship W2077107039A5061595379 @default.
- W2077107039 hasAuthorship W2077107039A5087348549 @default.
- W2077107039 hasBestOaLocation W20771070391 @default.
- W2077107039 hasConcept C126322002 @default.
- W2077107039 hasConcept C134018914 @default.
- W2077107039 hasConcept C15744967 @default.
- W2077107039 hasConcept C2779134260 @default.
- W2077107039 hasConcept C2780841215 @default.
- W2077107039 hasConcept C2781161787 @default.
- W2077107039 hasConcept C57089818 @default.
- W2077107039 hasConcept C71924100 @default.
- W2077107039 hasConceptScore W2077107039C126322002 @default.
- W2077107039 hasConceptScore W2077107039C134018914 @default.