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- W2077108120 abstract "Abstract Production of organic acids by microorganisms is of great importance for obtaining building-block chemicals from sustainable biomass. Extracellular accumulation of organic acids involved a series of transporters, which play important roles in the accumulation of specific organic acid while lack of systematic demonstration in eukaryotic microorganisms. To circumvent accumulation of by-product, efforts have being orchestrated to carboxylate transport mechanism for potential clue in Yarrowia lipolytica WSH-Z06. Six endogenous putative transporter genes, YALI0B19470g, YALI0C15488g, YALI0C21406g, YALI0D24607g, YALI0D20108g and YALI0E32901g, were identified. Transport characteristics and substrate specificities were further investigated using a carboxylate-transport-deficient Saccharomyces cerevisiae strain. These transporters were expressed in Y . lipolytica WSH-Z06 to assess their roles in regulating extracellular keto acids accumulation. In a Y . lipolytica T1 line over expressing YALI0B19470g, α-ketoglutarate accumulated to 46.7 g·L −1 , whereas the concentration of pyruvate decreased to 12.3 g·L −1 . Systematic identification of these keto acids transporters would provide clues to further improve the accumulation of specific organic acids with higher efficiency in eukaryotic microorganisms." @default.
- W2077108120 created "2016-06-24" @default.
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- W2077108120 date "2015-01-30" @default.
- W2077108120 modified "2023-09-25" @default.
- W2077108120 title "Identification and application of keto acids transporters in Yarrowia lipolytica" @default.
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- W2077108120 doi "https://doi.org/10.1038/srep08138" @default.
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