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- W2077109488 abstract "There is ample evidence from animal models indicating that secretion of atrial natriuretic factor (ANF) can be induced by an increase in atrial contraction frequency or atrial distension. The influence of these stimulatory signals on ANF secretion in humans has not been fully elucidated. We assessed the responses to graded right atrial pacing in 28 patients (aged 33 to 70 years) at rates of 100, 125, and 150 beata/min on right atrial pressure, left atrial size (by two-dimensional echocardiography in 9 of 28 patients), and circulating plasma ANF levels. At pacing rates of 125 and 150 beats/min, ANF levels increased from a baseline value of 64 ± 9 fmol/ml (mean ± SEM) to 89 ± 13 fmol/ml (pp < 0.05) and to 132 ± 17 fmol/ml, respectively (p < 0.001). Right atrial pressure increased from a baseline value of 4.1 ± 0.7 mm Hg to 4.5 ± 0.6 mm Hg at a pacing rate of 125 beats/min (p < 0.05) and to 6.1 ± 0.8 mm Hg at a pacing rate of 150 beats/min (p < 0.001). Left atrial dimension increased from a baseline value of 44.5 ± 3 mm to 49.5 ± 3 mm at a pacing rate of 125 beats/min (p < 0.05) and increased further to 52.5 ± 3 mm at a pacing rate of 150 beats/min (p < 0.001). No significant changes in atrial pressure or size or in plasma ANF were observed at a pacing rate of 100 beats/min. These data suggest that increased atrial distension and intracavitary pressure result from higher atrial pacing frequencies (125 and 150 beats/min) and contribute significantly to increased circulating ANF levels in humans. An independent effect of atrial pacing frequency on plasma ANF in humans could not be identified." @default.
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- W2077109488 date "1988-08-01" @default.
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- W2077109488 title "Atrial natriuretic factor release is enhanced by incremental atrial pacing" @default.
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- W2077109488 doi "https://doi.org/10.1016/0002-8703(88)90622-9" @default.
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