Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077109766> ?p ?o ?g. }
- W2077109766 endingPage "6086" @default.
- W2077109766 startingPage "6082" @default.
- W2077109766 abstract "We have shown previously the existence of small, activity-dependent changes in intrinsic optical properties of cortex that are useful for optical imaging of cortical functional architecture. In this study we introduce a higher resolution optical imaging system that offers spatial and temporal resolution exceeding that achieved by most alternative imaging techniques for imaging cortical functional architecture or for monitoring local changes in cerebral blood volume or oxygen saturation. In addition, we investigated the mechanisms responsible for the activity-dependent intrinsic signals evoked by sensory stimuli, and studied their origins and wavelength dependence. These studies enabled high-resolution visualization of cortical functional architecture at wavelengths ranging from 480 to 940 nm. With the use of near-infrared illumination it was possible to image cortical functional architecture through the intact dura or even through a thinned skull. In addition, the same imaging technique proved useful for imaging and discriminating sensory-evoked, activity-dependent changes in local blood volume and oxygen saturation (oxygen delivery). Illumination at 570 nm allowed imaging of activity-dependent blood volume increases, whereas at 600-630 nm, the predominant signal probably originated from activity-dependent oxygen delivery from capillaries. The onset of oxygen delivery started prior to the blood volume increase. Thus, optical imaging based on intrinsic signals is a minimally invasive procedure for monitoring short- and long-term changes in cerebral activity." @default.
- W2077109766 created "2016-06-24" @default.
- W2077109766 creator A5008819147 @default.
- W2077109766 creator A5018951939 @default.
- W2077109766 creator A5036142011 @default.
- W2077109766 creator A5087504327 @default.
- W2077109766 date "1990-08-01" @default.
- W2077109766 modified "2023-10-17" @default.
- W2077109766 title "Cortical functional architecture and local coupling between neuronal activity and the microcirculation revealed by in vivo high-resolution optical imaging of intrinsic signals." @default.
- W2077109766 cites W1563994448 @default.
- W2077109766 cites W1783343300 @default.
- W2077109766 cites W1953519581 @default.
- W2077109766 cites W1964562899 @default.
- W2077109766 cites W1971337374 @default.
- W2077109766 cites W1980313062 @default.
- W2077109766 cites W1983924090 @default.
- W2077109766 cites W1988183161 @default.
- W2077109766 cites W1988561713 @default.
- W2077109766 cites W1993303421 @default.
- W2077109766 cites W1994364310 @default.
- W2077109766 cites W1994971749 @default.
- W2077109766 cites W1995467519 @default.
- W2077109766 cites W1997457635 @default.
- W2077109766 cites W2007494471 @default.
- W2077109766 cites W2015382915 @default.
- W2077109766 cites W2027645979 @default.
- W2077109766 cites W2034219019 @default.
- W2077109766 cites W2053356496 @default.
- W2077109766 cites W2061393851 @default.
- W2077109766 cites W2064234151 @default.
- W2077109766 cites W2068417948 @default.
- W2077109766 cites W2072227605 @default.
- W2077109766 cites W2084000381 @default.
- W2077109766 cites W2111762111 @default.
- W2077109766 cites W2116360511 @default.
- W2077109766 cites W2126217563 @default.
- W2077109766 cites W2198062837 @default.
- W2077109766 cites W2429658542 @default.
- W2077109766 cites W2469210314 @default.
- W2077109766 doi "https://doi.org/10.1073/pnas.87.16.6082" @default.
- W2077109766 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/54476" @default.
- W2077109766 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2117272" @default.
- W2077109766 hasPublicationYear "1990" @default.
- W2077109766 type Work @default.
- W2077109766 sameAs 2077109766 @default.
- W2077109766 citedByCount "894" @default.
- W2077109766 countsByYear W20771097662012 @default.
- W2077109766 countsByYear W20771097662013 @default.
- W2077109766 countsByYear W20771097662014 @default.
- W2077109766 countsByYear W20771097662015 @default.
- W2077109766 countsByYear W20771097662016 @default.
- W2077109766 countsByYear W20771097662017 @default.
- W2077109766 countsByYear W20771097662018 @default.
- W2077109766 countsByYear W20771097662019 @default.
- W2077109766 countsByYear W20771097662020 @default.
- W2077109766 countsByYear W20771097662021 @default.
- W2077109766 countsByYear W20771097662022 @default.
- W2077109766 countsByYear W20771097662023 @default.
- W2077109766 crossrefType "journal-article" @default.
- W2077109766 hasAuthorship W2077109766A5008819147 @default.
- W2077109766 hasAuthorship W2077109766A5018951939 @default.
- W2077109766 hasAuthorship W2077109766A5036142011 @default.
- W2077109766 hasAuthorship W2077109766A5087504327 @default.
- W2077109766 hasBestOaLocation W20771097661 @default.
- W2077109766 hasConcept C119666444 @default.
- W2077109766 hasConcept C120665830 @default.
- W2077109766 hasConcept C121332964 @default.
- W2077109766 hasConcept C12554922 @default.
- W2077109766 hasConcept C136229726 @default.
- W2077109766 hasConcept C146957229 @default.
- W2077109766 hasConcept C150903083 @default.
- W2077109766 hasConcept C164705383 @default.
- W2077109766 hasConcept C169760540 @default.
- W2077109766 hasConcept C182752723 @default.
- W2077109766 hasConcept C185592680 @default.
- W2077109766 hasConcept C192562407 @default.
- W2077109766 hasConcept C207001950 @default.
- W2077109766 hasConcept C2779345533 @default.
- W2077109766 hasConcept C29331040 @default.
- W2077109766 hasConcept C2982720008 @default.
- W2077109766 hasConcept C37557685 @default.
- W2077109766 hasConcept C71924100 @default.
- W2077109766 hasConcept C86803240 @default.
- W2077109766 hasConcept C92630104 @default.
- W2077109766 hasConceptScore W2077109766C119666444 @default.
- W2077109766 hasConceptScore W2077109766C120665830 @default.
- W2077109766 hasConceptScore W2077109766C121332964 @default.
- W2077109766 hasConceptScore W2077109766C12554922 @default.
- W2077109766 hasConceptScore W2077109766C136229726 @default.
- W2077109766 hasConceptScore W2077109766C146957229 @default.
- W2077109766 hasConceptScore W2077109766C150903083 @default.
- W2077109766 hasConceptScore W2077109766C164705383 @default.
- W2077109766 hasConceptScore W2077109766C169760540 @default.
- W2077109766 hasConceptScore W2077109766C182752723 @default.
- W2077109766 hasConceptScore W2077109766C185592680 @default.
- W2077109766 hasConceptScore W2077109766C192562407 @default.
- W2077109766 hasConceptScore W2077109766C207001950 @default.
- W2077109766 hasConceptScore W2077109766C2779345533 @default.