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- W2077113145 abstract "The corneal endothelium is a monolayer that mediates the flux of solutes and water across the posterior corneal surface. Thereby, it plays an essential role to maintain the transparency of the cornea. Unlike the epithelium, the human endothelium is an amitotic cell layer with a critical cell density and the risk of corneal decompensation. The number of endothelial cells subsequently decreases with age. Moreover, the endothelial cell loss is accelerated after various impairments such as surgical trauma (e.g. cataract extraction) and following corneal transplantation. This cell loss is associated with programmed cell death (apoptosis) and changed ion channel activity. However, little is known about the electrophysiology and ion channel expression (in particular Ca2+ channels) in corneal endothelial cells. This article reviews our current knowledge about the electrophysiology of the corneal endothelium. It highlights ion channel expression, which may have a major role in corneal cell physiology and pathological events. A better understanding of the (electro)physiological function of the cornea may lead to the development of clinical relevant new therapeutic and preventive measures." @default.
- W2077113145 created "2016-06-24" @default.
- W2077113145 creator A5059499344 @default.
- W2077113145 creator A5086161688 @default.
- W2077113145 date "2007-07-01" @default.
- W2077113145 modified "2023-10-01" @default.
- W2077113145 title "The human corneal endothelium: New insights into electrophysiology and ion channels" @default.
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