FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077116102> ?p ?o ?g. }

• W2077116102 endingPage "6880" @default.
• W2077116102 startingPage "6867" @default.
• W2077116102 abstract "ABSTRACT Cell cycle progression and polar differentiation are temporally coordinated in Caulobacter crescentus . This oligotrophic bacterium divides asymmetrically to produce a motile swarmer cell that represses DNA replication and a sessile stalked cell that replicates its DNA. The initiation of DNA replication coincides with the proteolysis of the CtrA replication inhibitor and the accumulation of DnaA, the replication initiator, upon differentiation of the swarmer cell into a stalked cell. We analyzed the adaptive response of C. crescentus swarmer cells to carbon starvation and found that there was a block in both the swarmer-to-stalked cell polar differentiation program and the initiation of DNA replication. SpoT is a bifunctional synthase/hydrolase that controls the steady-state level of the stress-signaling nucleotide (p)ppGpp, and carbon starvation caused a SpoT-dependent increase in (p)ppGpp concentration. Carbon starvation activates DnaA proteolysis (B. Gorbatyuk and G. T. Marczynski, Mol. Microbiol. 55: 1233-1245, 2005). We observed that SpoT is required for this phenomenon in swarmer cells, and in the absence of SpoT, carbon-starved swarmer cells inappropriately initiated DNA replication. Since SpoT controls (p)ppGpp abundance, we propose that this nucleotide relays carbon starvation signals to the cellular factors responsible for activating DnaA proteolysis, thereby inhibiting the initiation of DNA replication. SpoT, however, was not required for the carbon starvation block of the swarmer-to-stalked cell polar differentiation program. Thus, swarmer cells utilize at least two independent signaling pathways to relay carbon starvation signals: a SpoT-dependent pathway mediating the inhibition of DNA replication initiation, and a SpoT-independent pathway(s) that blocks morphological differentiation." @default.
• W2077116102 created "2016-06-24" @default.
• W2077116102 creator A5046969034 @default.
• W2077116102 creator A5089781281 @default.
• W2077116102 date "2008-10-15" @default.
• W2077116102 modified "2023-10-14" @default.
• W2077116102 title "SpoT Regulates DnaA Stability and Initiation of DNA Replication in Carbon-Starved <i>Caulobacter crescentus</i>" @default.
• W2077116102 cites W149767863 @default.
• W2077116102 cites W1523304298 @default.
• W2077116102 cites W1531468991 @default.
• W2077116102 cites W1538286201 @default.
• W2077116102 cites W1545099482 @default.
• W2077116102 cites W1553669032 @default.
• W2077116102 cites W1581151139 @default.
• W2077116102 cites W1599071123 @default.
• W2077116102 cites W1616230851 @default.
• W2077116102 cites W1779813939 @default.
• W2077116102 cites W1879277727 @default.
• W2077116102 cites W1891685870 @default.
• W2077116102 cites W1907864307 @default.
• W2077116102 cites W1971507610 @default.
• W2077116102 cites W1975473030 @default.
• W2077116102 cites W1985253447 @default.
• W2077116102 cites W1990048403 @default.
• W2077116102 cites W1992236963 @default.
• W2077116102 cites W1995424951 @default.
• W2077116102 cites W2006257982 @default.
• W2077116102 cites W2008687368 @default.
• W2077116102 cites W2012393398 @default.
• W2077116102 cites W2012511424 @default.
• W2077116102 cites W2030113713 @default.
• W2077116102 cites W2034750183 @default.
• W2077116102 cites W2035385414 @default.
• W2077116102 cites W2039113975 @default.
• W2077116102 cites W2043129236 @default.
• W2077116102 cites W2046901711 @default.
• W2077116102 cites W2048007683 @default.
• W2077116102 cites W2048529632 @default.
• W2077116102 cites W2049076326 @default.
• W2077116102 cites W2054618215 @default.
• W2077116102 cites W2061135731 @default.
• W2077116102 cites W2061709949 @default.
• W2077116102 cites W2072096103 @default.
• W2077116102 cites W2075532221 @default.
• W2077116102 cites W2077643009 @default.
• W2077116102 cites W2077903098 @default.
• W2077116102 cites W2082544747 @default.
• W2077116102 cites W2097101221 @default.
• W2077116102 cites W2097896589 @default.
• W2077116102 cites W2104967054 @default.
• W2077116102 cites W2108336065 @default.
• W2077116102 cites W2114648588 @default.
• W2077116102 cites W2114755129 @default.
• W2077116102 cites W2119896573 @default.
• W2077116102 cites W2125376264 @default.
• W2077116102 cites W2130172998 @default.
• W2077116102 cites W2132522708 @default.
• W2077116102 cites W2132957039 @default.
• W2077116102 cites W2135202729 @default.
• W2077116102 cites W2141378551 @default.
• W2077116102 cites W2145373765 @default.
• W2077116102 cites W2146562435 @default.
• W2077116102 cites W2147270077 @default.
• W2077116102 cites W2155269552 @default.
• W2077116102 cites W2155608445 @default.
• W2077116102 cites W2164380664 @default.
• W2077116102 cites W2164856850 @default.
• W2077116102 cites W2169856943 @default.
• W2077116102 cites W950515816 @default.
• W2077116102 doi "https://doi.org/10.1128/jb.00700-08" @default.
• W2077116102 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2566184" @default.
• W2077116102 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18723629" @default.
• W2077116102 hasPublicationYear "2008" @default.
• W2077116102 type Work @default.
• W2077116102 sameAs 2077116102 @default.
• W2077116102 citedByCount "98" @default.
• W2077116102 countsByYear W20771161022012 @default.
• W2077116102 countsByYear W20771161022013 @default.
• W2077116102 countsByYear W20771161022014 @default.
• W2077116102 countsByYear W20771161022015 @default.
• W2077116102 countsByYear W20771161022016 @default.
• W2077116102 countsByYear W20771161022017 @default.
• W2077116102 countsByYear W20771161022018 @default.
• W2077116102 countsByYear W20771161022019 @default.
• W2077116102 countsByYear W20771161022020 @default.
• W2077116102 countsByYear W20771161022021 @default.
• W2077116102 countsByYear W20771161022022 @default.
• W2077116102 countsByYear W20771161022023 @default.
• W2077116102 crossrefType "journal-article" @default.
• W2077116102 hasAuthorship W2077116102A5046969034 @default.
• W2077116102 hasAuthorship W2077116102A5089781281 @default.
• W2077116102 hasBestOaLocation W20771161022 @default.
• W2077116102 hasConcept C107827726 @default.
• W2077116102 hasConcept C1491633281 @default.
• W2077116102 hasConcept C2778767192 @default.
• W2077116102 hasConcept C29537977 @default.
• W2077116102 hasConcept C54355233 @default.
• W2077116102 hasConcept C552990157 @default.

• next