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• W2077122952 startingPage "1" @default.
• W2077122952 abstract "Haematopoietic stem cell transplantation (HSCT) is a valuable tool in the treatment of many haematological disorders. Advances in understanding HLA matching have improved prognoses. However, many recipients of well-matched HSCT develop posttransplant complications, and survival is far from absolute. The pursuit of novel genetic factors that may impact on HSCT outcome has resulted in the publication of many articles on a multitude of genes. Three NOD2 polymorphisms, identified as disease-associated variants in Crohn’s disease, have recently been suggested as important candidate gene markers in the outcome of HSCT. It was originally postulated that as the clinical manifestation of inflammatory responses characteristic of several post-transplant complications was of notable similarity to those seen in Crohn’s disease, it was possible that they shared a common cause. Since the publication of this first paper, numerous studies have attempted to replicate the results in different transplant settings. The data has varied considerably between studies, and as yet no consensus on the impact of NOD2 SNPs on HSCT outcome has been achieved. Here, we will review the existing literature, summarise current theories as to why the data differs, and suggest possible mechanisms by which the SNPs affect HSCT outcome." @default.
• W2077122952 created "2016-06-24" @default.
• W2077122952 creator A5019858492 @default.
• W2077122952 creator A5032478325 @default.
• W2077122952 creator A5036511174 @default.
• W2077122952 creator A5072209951 @default.
• W2077122952 date "2012-10-18" @default.
• W2077122952 modified "2023-10-03" @default.
• W2077122952 title "<i>NOD2</i> Polymorphisms and Their Impact on Haematopoietic Stem Cell Transplant Outcome" @default.
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