Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077126688> ?p ?o ?g. }
Showing items 1 to 55 of
55
with 100 items per page.
- W2077126688 endingPage "419" @default.
- W2077126688 startingPage "418" @default.
- W2077126688 abstract "The recent editorial1 supporting initial treatment of early onset Parkinson's disease with a dopamine agonist hinged in part on the demonstration2 in 268 patients that treatment of early onset Parkinson's disease with ropinirole alone or with supplementary levodopa/dopa decarboxylase inhibitor (benserazide) (LD/DDI) resulted in substantially less dyskinesia than with LD/DDI alone, with only slightly less motor benefit. Five per cent of patients on ropinirole alone developed dyskinesia after 5 years, compared with 25% with ropinirole plus LD/DDI, and 45% of those on LD/DDI alone). The trial design allowed LD/DDI supplementation if response was inadequate and additional trial drug could not be tolerated. Up to 24 mg ropinirole and 1200 mg LD/DDI daily were allowed. Sixty six per cent of patients completing the ropinirole arm required supplementation, the average mean daily dose of ropinirole at 5 years being 16.5 mg, compared with 753 mg of LD/DDI when the second was used alone.It is unfortunate that the study required a three times daily dosage regime. It seems possible that this accounts for the surprising 33% of patients on LD/DDI …" @default.
- W2077126688 created "2016-06-24" @default.
- W2077126688 creator A5074432479 @default.
- W2077126688 date "2001-03-01" @default.
- W2077126688 modified "2023-09-23" @default.
- W2077126688 title "Treatment of early onset Parkinson's disease with ropinirole" @default.
- W2077126688 cites W1995262065 @default.
- W2077126688 cites W2114122417 @default.
- W2077126688 cites W2322912881 @default.
- W2077126688 doi "https://doi.org/10.1136/jnnp.70.3.418" @default.
- W2077126688 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1737235" @default.
- W2077126688 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11248906" @default.
- W2077126688 hasPublicationYear "2001" @default.
- W2077126688 type Work @default.
- W2077126688 sameAs 2077126688 @default.
- W2077126688 citedByCount "0" @default.
- W2077126688 crossrefType "journal-article" @default.
- W2077126688 hasAuthorship W2077126688A5074432479 @default.
- W2077126688 hasBestOaLocation W20771266882 @default.
- W2077126688 hasConcept C126322002 @default.
- W2077126688 hasConcept C2777453868 @default.
- W2077126688 hasConcept C2779134260 @default.
- W2077126688 hasConcept C2779734285 @default.
- W2077126688 hasConcept C2780304432 @default.
- W2077126688 hasConcept C71924100 @default.
- W2077126688 hasConceptScore W2077126688C126322002 @default.
- W2077126688 hasConceptScore W2077126688C2777453868 @default.
- W2077126688 hasConceptScore W2077126688C2779134260 @default.
- W2077126688 hasConceptScore W2077126688C2779734285 @default.
- W2077126688 hasConceptScore W2077126688C2780304432 @default.
- W2077126688 hasConceptScore W2077126688C71924100 @default.
- W2077126688 hasIssue "3" @default.
- W2077126688 hasLocation W20771266881 @default.
- W2077126688 hasLocation W20771266882 @default.
- W2077126688 hasLocation W20771266883 @default.
- W2077126688 hasLocation W20771266884 @default.
- W2077126688 hasOpenAccess W2077126688 @default.
- W2077126688 hasPrimaryLocation W20771266881 @default.
- W2077126688 hasRelatedWork W1943258521 @default.
- W2077126688 hasRelatedWork W2021672890 @default.
- W2077126688 hasRelatedWork W2081979418 @default.
- W2077126688 hasRelatedWork W2092061294 @default.
- W2077126688 hasRelatedWork W2151039555 @default.
- W2077126688 hasRelatedWork W3204180976 @default.
- W2077126688 hasRelatedWork W4221134541 @default.
- W2077126688 hasRelatedWork W4231453436 @default.
- W2077126688 hasRelatedWork W4300195350 @default.
- W2077126688 hasRelatedWork W634144214 @default.
- W2077126688 hasVolume "70" @default.
- W2077126688 isParatext "false" @default.
- W2077126688 isRetracted "false" @default.
- W2077126688 magId "2077126688" @default.
- W2077126688 workType "article" @default.