FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077134054> ?p ?o ?g. }

• W2077134054 endingPage "14510" @default.
• W2077134054 startingPage "14489" @default.
• W2077134054 abstract "Inflammation features in CNS disorders such as stroke, trauma, neurodegeneration, infection, and autoimmunity in which astrocytes play critical roles. To elucidate how inflammatory mediators alter astrocyte functions, we examined effects of transforming growth factor-β1 (TGF-β1), lipopolysaccharide (LPS), and interferon-gamma (IFNγ), alone and in combination, on purified, mouse primary cortical astrocyte cultures. We used microarrays to conduct whole-genome expression profiling, and measured calcium signaling, which is implicated in mediating dynamic astrocyte functions. Combinatorial exposure to TGF-β1, LPS, and IFNγ significantly modulated astrocyte expression of >6800 gene probes, including >380 synergistic changes not predicted by summing individual treatment effects. Bioinformatic analyses revealed significantly and markedly upregulated molecular networks and pathways associated in particular with immune signaling and regulation of cell injury, death, growth, and proliferation. Highly regulated genes included chemokines, growth factors, enzymes, channels, transporters, and intercellular and intracellular signal transducers. Notably, numerous genes for G-protein-coupled receptors (GPCRs) and G-protein effectors involved in calcium signaling were significantly regulated, mostly down (for example, Cxcr4, Adra2a, Ednra, P2ry1, Gnao1, Gng7), but some up (for example, P2ry14, P2ry6, Ccrl2, Gnb4). We tested selected cases and found that changes in GPCR gene expression were accompanied by significant, parallel changes in astrocyte calcium signaling evoked by corresponding GPCR-specific ligands. These findings identify pronounced changes in the astrocyte transcriptome induced by TGF-β1, LPS, and IFNγ, and show that these inflammatory stimuli upregulate astrocyte molecular networks associated with immune- and injury-related functions and significantly alter astrocyte calcium signaling stimulated by multiple GPCRs." @default.
• W2077134054 created "2016-06-24" @default.
• W2077134054 creator A5009669991 @default.
• W2077134054 creator A5011858801 @default.
• W2077134054 creator A5018481303 @default.
• W2077134054 creator A5022439012 @default.
• W2077134054 creator A5041132154 @default.
• W2077134054 creator A5062316104 @default.
• W2077134054 date "2012-10-17" @default.
• W2077134054 modified "2023-10-05" @default.
• W2077134054 title "Inflammatory Mediators Alter the Astrocyte Transcriptome and Calcium Signaling Elicited by Multiple G-Protein-Coupled Receptors" @default.
• W2077134054 cites W13190598 @default.
• W2077134054 cites W1488352046 @default.
• W2077134054 cites W1594425991 @default.
• W2077134054 cites W1902112862 @default.
• W2077134054 cites W1969223713 @default.
• W2077134054 cites W1969619562 @default.
• W2077134054 cites W1970345181 @default.
• W2077134054 cites W1971285535 @default.
• W2077134054 cites W1982007787 @default.
• W2077134054 cites W1982051575 @default.
• W2077134054 cites W1986004422 @default.
• W2077134054 cites W1988881559 @default.
• W2077134054 cites W1996696087 @default.
• W2077134054 cites W2003604887 @default.
• W2077134054 cites W2006289803 @default.
• W2077134054 cites W2007147688 @default.
• W2077134054 cites W2011331227 @default.
• W2077134054 cites W2011343276 @default.
• W2077134054 cites W2015759485 @default.
• W2077134054 cites W2020138925 @default.
• W2077134054 cites W2020541351 @default.
• W2077134054 cites W2021897449 @default.
• W2077134054 cites W2022908550 @default.
• W2077134054 cites W2024490058 @default.
• W2077134054 cites W2034800617 @default.
• W2077134054 cites W2044057452 @default.
• W2077134054 cites W2047420197 @default.
• W2077134054 cites W2047928629 @default.
• W2077134054 cites W2050417355 @default.
• W2077134054 cites W2050744136 @default.
• W2077134054 cites W2054737835 @default.
• W2077134054 cites W2059172386 @default.
• W2077134054 cites W2060319077 @default.
• W2077134054 cites W2073526402 @default.
• W2077134054 cites W2074661552 @default.
• W2077134054 cites W2081098333 @default.
• W2077134054 cites W2084566588 @default.
• W2077134054 cites W2085424855 @default.
• W2077134054 cites W2086180819 @default.
• W2077134054 cites W2086237072 @default.
• W2077134054 cites W2086436146 @default.
• W2077134054 cites W2096392022 @default.
• W2077134054 cites W2096687088 @default.
• W2077134054 cites W2101363175 @default.
• W2077134054 cites W2102571106 @default.
• W2077134054 cites W2103037576 @default.
• W2077134054 cites W2104146721 @default.
• W2077134054 cites W2106829291 @default.
• W2077134054 cites W2108301498 @default.
• W2077134054 cites W2108971625 @default.
• W2077134054 cites W2113679292 @default.
• W2077134054 cites W2121860798 @default.
• W2077134054 cites W2122665472 @default.
• W2077134054 cites W2124940469 @default.
• W2077134054 cites W2127471055 @default.
• W2077134054 cites W2127621191 @default.
• W2077134054 cites W2127634810 @default.
• W2077134054 cites W2135376726 @default.
• W2077134054 cites W2138975833 @default.
• W2077134054 cites W2151201627 @default.
• W2077134054 cites W2155215831 @default.
• W2077134054 cites W2160500827 @default.
• W2077134054 cites W2160935383 @default.
• W2077134054 cites W2161612497 @default.
• W2077134054 cites W2163234334 @default.
• W2077134054 cites W2167017590 @default.
• W2077134054 cites W2169518110 @default.
• W2077134054 cites W2171335055 @default.
• W2077134054 cites W4234317413 @default.
• W2077134054 cites W4255760236 @default.
• W2077134054 doi "https://doi.org/10.1523/jneurosci.1256-12.2012" @default.
• W2077134054 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3518872" @default.
• W2077134054 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23077035" @default.
• W2077134054 hasPublicationYear "2012" @default.
• W2077134054 type Work @default.
• W2077134054 sameAs 2077134054 @default.
• W2077134054 citedByCount "170" @default.
• W2077134054 countsByYear W20771340542012 @default.
• W2077134054 countsByYear W20771340542013 @default.
• W2077134054 countsByYear W20771340542014 @default.
• W2077134054 countsByYear W20771340542015 @default.
• W2077134054 countsByYear W20771340542016 @default.
• W2077134054 countsByYear W20771340542017 @default.
• W2077134054 countsByYear W20771340542018 @default.
• W2077134054 countsByYear W20771340542019 @default.
• W2077134054 countsByYear W20771340542020 @default.
• W2077134054 countsByYear W20771340542021 @default.

• next