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- W2077148148 abstract "The time course of visually evoked responses (VER's) recorded at the cortex were studied in rats during addiction and withdrawal. Data for peak-to-peak amplitudes, latencies and photic afterdischarges (PhAD's) were collected on the fifth, eleventh and seventeenth days of addiction, on the day of withdrawal and on the first, second and seventh days postwithdrawal. For the ethanol group during the addiction phase, amplitude and PhAD measures were depressed at the first recording session (day 5) and remained so throughout the addiction phase. Latency data, however, revealed a progressive increase to major peaks throughout the addiction phase that reached significance for P2 on day 17. VER amplitudes and PhAD excursion values were depressed and latencies increased, relative to controls, at the end of the addiction phase. On the day of withdrawal (day 0), P3-N3 amplitudes and PhAD excursion values remained significantly depressed relative to controls. Amplitude measures for other individual components had returned to control levels but had not yet exhibited rebound (neural hyperexcitability). Latency measures remained unchanged during day 0 testing and demonstrated a recovery to control levels by day 1 or 2 postwithdrawal. On day 1 postwithdrawal, amplitude and PhAD measures reflected neural hyperexcitability that remained throughout the seventh day although the decline in amplitudes between the second and seventh day of postwithdrawal testing suggested a trend toward neural recovery. The time course of VER amplitudes and latencies and the PhAD during addiction and withdrawal are discussed." @default.
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- W2077148148 title "Effects of alcohol on visually evoked responses in rats during addiction and withdrawal" @default.
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- W2077148148 doi "https://doi.org/10.1016/0091-3057(80)90452-9" @default.
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