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• W2077148934 abstract "The rat lumbar spinal cord contains the testosterone-dependent spinal nucleus of the bulbocavernosus (SNB), whose motoneurons innervate perineal muscles involved in copulatory reflexes. In normal males, SNB dendrites grow exuberantly through the first 4 weeks postnatally. This growth is steroid-dependent: dendrites fail to grow in males castrated at P7, but grow normally in castrates treated with testosterone (T). Treatment with either of the T metabolites, dihydrotestosterone or estrogen, supports dendritic growth in castrates, but not to the lengths characteristic of intact males or T-treated castrates. The present study tested the hypothesis that dihydrotestosterone and estrogen act together to support development of SNB dendrites. Male rat pups were castrated on P7 and treated daily with dihydrotestosterone propionate (DHT) (2 mg), estradiol benzoate (E) (100 μg), DHT (2 mg) combined with estradiol benzoate in either 5 μg (E5) or 100 μg (E100) doses, or vehicle alone. On P28, when SNB dendritic length is normally maximal, motoneurons were retrogradely labeled with cholera toxin-HRP (BHRP). Soma size and dendritic lengths of labeled motoneurons were assessed and compared to those of age-matched, intact male rats. Soma areas of DHT + E5-treated and DHT + E100-treated castrates did not differ from those of castrates treated with DHT alone, although somata of all three groups were significantly larger than those of normal males and E- or oil-treated castrates. Dendritic lengths in DHT + E5-treated castrates were significantly shorter than those of normal males, and did not differ from those of castrates receiving DHT or E alone, although all hormone-treated groups had dendritic lengths that were significantly longer than untreated castrates. However, treatment of castrates with DHT + E100 fully supported dendritic growth to levels characteristic of normal males. These results suggest that somal and dendritic growth may occur through separate developmental mechanisms, and that E and DHT act synergistically to support normal masculine SNB dendritic development. © 1997 John Wiley & Sons, Inc. J Neurobiol 33: 1–10, 1997" @default.
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• W2077148934 date "1997-07-01" @default.
• W2077148934 modified "2023-10-12" @default.
• W2077148934 title "Synergistic effects of testosterone metabolites on the development of motoneuron morphology in a sexually dimorphic rat spinal nucleus" @default.
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• W2077148934 doi "https://doi.org/10.1002/(sici)1097-4695(199707)33:1<1::aid-neu1>3.0.co;2-7" @default.
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