FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077151111> ?p ?o ?g. }

• W2077151111 endingPage "3091" @default.
• W2077151111 startingPage "3087" @default.
• W2077151111 abstract "The acyclic purine nucleoside analogue 9-(2-phosphonomethoxyethyl)adenine [PMEA; formerly referred to as 9-(2-phosphonylmethoxyethyl)adenine] is a potent and selective inhibitor of human immunodeficiency virus replication in vitro and of Moloney murine sarcoma virus-induced tumor formation in mice. In the latter system PMEA has stronger antiretroviral potency and selectivity than 3'-azido-3'-thymidine (AZT). We have now investigated the effect of the drug in cats infected with the feline immunodeficiency virus (FIV). In vitro, PMEA was found to efficiently block FIV replication in feline thymocytes (50% effective dose, 0.6 microM). When administered to cats at doses of 20, 5, or 2 mg/kg per day, PMEA caused a dose-dependent suppression of FIV replication and virus-specific antibody production. Seropositive field cats with signs of opportunistic infection (gingivitis, stomatitis, and diarrhea) showed clinical improvement during PMEA therapy (5 mg/kg per day) and recurrence of the disease after treatment was discontinued. Thus, FIV infection in cats is an excellent model to test the efficacy of selective anti-human immunodeficiency virus agents in vivo." @default.
• W2077151111 created "2016-06-24" @default.
• W2077151111 creator A5036402779 @default.
• W2077151111 creator A5038319371 @default.
• W2077151111 creator A5038693465 @default.
• W2077151111 creator A5040662398 @default.
• W2077151111 creator A5050603816 @default.
• W2077151111 creator A5052179333 @default.
• W2077151111 creator A5053887406 @default.
• W2077151111 creator A5063510237 @default.
• W2077151111 creator A5085813417 @default.
• W2077151111 date "1990-04-01" @default.
• W2077151111 modified "2023-09-26" @default.
• W2077151111 title "Suppression of feline immunodeficiency virus infection in vivo by 9-(2-phosphonomethoxyethyl)adenine." @default.
• W2077151111 cites W116619909 @default.
• W2077151111 cites W1492962073 @default.
• W2077151111 cites W1509988813 @default.
• W2077151111 cites W1531920376 @default.
• W2077151111 cites W1968873679 @default.
• W2077151111 cites W1977282539 @default.
• W2077151111 cites W1984958054 @default.
• W2077151111 cites W1986812169 @default.
• W2077151111 cites W1996511633 @default.
• W2077151111 cites W2017754417 @default.
• W2077151111 cites W2021453978 @default.
• W2077151111 cites W2037835396 @default.
• W2077151111 cites W2051531545 @default.
• W2077151111 cites W2063688561 @default.
• W2077151111 cites W2073017329 @default.
• W2077151111 cites W2082361721 @default.
• W2077151111 cites W2090540494 @default.
• W2077151111 cites W2092984137 @default.
• W2077151111 cites W2106371912 @default.
• W2077151111 cites W2108161758 @default.
• W2077151111 cites W2122395850 @default.
• W2077151111 cites W2136957906 @default.
• W2077151111 cites W2142447649 @default.
• W2077151111 cites W2143788821 @default.
• W2077151111 cites W2279793670 @default.
• W2077151111 cites W2333399282 @default.
• W2077151111 doi "https://doi.org/10.1073/pnas.87.8.3087" @default.
• W2077151111 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/53839" @default.
• W2077151111 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2158102" @default.
• W2077151111 hasPublicationYear "1990" @default.
• W2077151111 type Work @default.
• W2077151111 sameAs 2077151111 @default.
• W2077151111 citedByCount "100" @default.
• W2077151111 countsByYear W20771511112012 @default.
• W2077151111 countsByYear W20771511112014 @default.
• W2077151111 countsByYear W20771511112015 @default.
• W2077151111 countsByYear W20771511112016 @default.
• W2077151111 countsByYear W20771511112018 @default.
• W2077151111 countsByYear W20771511112019 @default.
• W2077151111 countsByYear W20771511112020 @default.
• W2077151111 crossrefType "journal-article" @default.
• W2077151111 hasAuthorship W2077151111A5036402779 @default.
• W2077151111 hasAuthorship W2077151111A5038319371 @default.
• W2077151111 hasAuthorship W2077151111A5038693465 @default.
• W2077151111 hasAuthorship W2077151111A5040662398 @default.
• W2077151111 hasAuthorship W2077151111A5050603816 @default.
• W2077151111 hasAuthorship W2077151111A5052179333 @default.
• W2077151111 hasAuthorship W2077151111A5053887406 @default.
• W2077151111 hasAuthorship W2077151111A5063510237 @default.
• W2077151111 hasAuthorship W2077151111A5085813417 @default.
• W2077151111 hasBestOaLocation W20771511111 @default.
• W2077151111 hasConcept C126322002 @default.
• W2077151111 hasConcept C150903083 @default.
• W2077151111 hasConcept C159047783 @default.
• W2077151111 hasConcept C202751555 @default.
• W2077151111 hasConcept C203014093 @default.
• W2077151111 hasConcept C207001950 @default.
• W2077151111 hasConcept C2522874641 @default.
• W2077151111 hasConcept C2776543447 @default.
• W2077151111 hasConcept C2777108182 @default.
• W2077151111 hasConcept C2777333352 @default.
• W2077151111 hasConcept C2777841672 @default.
• W2077151111 hasConcept C2779468541 @default.
• W2077151111 hasConcept C2779690655 @default.
• W2077151111 hasConcept C2779692357 @default.
• W2077151111 hasConcept C2779904517 @default.
• W2077151111 hasConcept C2780216070 @default.
• W2077151111 hasConcept C2780727368 @default.
• W2077151111 hasConcept C55493867 @default.
• W2077151111 hasConcept C71924100 @default.
• W2077151111 hasConcept C86803240 @default.
• W2077151111 hasConcept C98274493 @default.
• W2077151111 hasConceptScore W2077151111C126322002 @default.
• W2077151111 hasConceptScore W2077151111C150903083 @default.
• W2077151111 hasConceptScore W2077151111C159047783 @default.
• W2077151111 hasConceptScore W2077151111C202751555 @default.
• W2077151111 hasConceptScore W2077151111C203014093 @default.
• W2077151111 hasConceptScore W2077151111C207001950 @default.
• W2077151111 hasConceptScore W2077151111C2522874641 @default.
• W2077151111 hasConceptScore W2077151111C2776543447 @default.
• W2077151111 hasConceptScore W2077151111C2777108182 @default.
• W2077151111 hasConceptScore W2077151111C2777333352 @default.
• W2077151111 hasConceptScore W2077151111C2777841672 @default.
• W2077151111 hasConceptScore W2077151111C2779468541 @default.

• next