Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077154906> ?p ?o ?g. }
- W2077154906 endingPage "64" @default.
- W2077154906 startingPage "55" @default.
- W2077154906 abstract "An individual's risk of developing cardiovascular disease (CVD) is influenced by genetic factors. This study focussed on mapping genetic loci for CVD-risk traits in a unique population isolate derived from Norfolk Island.This investigation focussed on 377 individuals descended from the population founders. Principal component analysis was used to extract orthogonal components from 11 cardiovascular risk traits. Multipoint variance component methods were used to assess genome-wide linkage using SOLAR to the derived factors. A total of 285 of the 377 related individuals were informative for linkage analysis.A total of 4 principal components accounting for 83% of the total variance were derived. Principal component 1 was loaded with body size indicators; principal component 2 with body size, cholesterol and triglyceride levels; principal component 3 with the blood pressures; and principal component 4 with LDL-cholesterol and total cholesterol levels. Suggestive evidence of linkage for principal component 2 (h(2) = 0.35) was observed on chromosome 5q35 (LOD = 1.85; p = 0.0008). While peak regions on chromosome 10p11.2 (LOD = 1.27; p = 0.005) and 12q13 (LOD = 1.63; p = 0.003) were observed to segregate with principal components 1 (h(2) = 0.33) and 4 (h(2) = 0.42), respectively.This study investigated a number of CVD risk traits in a unique isolated population. Findings support the clustering of CVD risk traits and provide interesting evidence of a region on chromosome 5q35 segregating with weight, waist circumference, HDL-c and total triglyceride levels." @default.
- W2077154906 created "2016-06-24" @default.
- W2077154906 creator A5004538115 @default.
- W2077154906 creator A5011126513 @default.
- W2077154906 creator A5017431021 @default.
- W2077154906 creator A5017852596 @default.
- W2077154906 creator A5032497724 @default.
- W2077154906 creator A5051538332 @default.
- W2077154906 creator A5062093157 @default.
- W2077154906 creator A5088012985 @default.
- W2077154906 creator A5091688246 @default.
- W2077154906 date "2009-01-01" @default.
- W2077154906 modified "2023-09-26" @default.
- W2077154906 title "Principal Component and Linkage Analysis of Cardiovascular Risk Traits in the Norfolk Isolate" @default.
- W2077154906 cites W1522183720 @default.
- W2077154906 cites W1971458029 @default.
- W2077154906 cites W1972101306 @default.
- W2077154906 cites W1976741643 @default.
- W2077154906 cites W1976950766 @default.
- W2077154906 cites W1977848689 @default.
- W2077154906 cites W1985908429 @default.
- W2077154906 cites W1991450386 @default.
- W2077154906 cites W1995404520 @default.
- W2077154906 cites W1997230217 @default.
- W2077154906 cites W1998866984 @default.
- W2077154906 cites W1999908627 @default.
- W2077154906 cites W2002697160 @default.
- W2077154906 cites W2007207726 @default.
- W2077154906 cites W2007239171 @default.
- W2077154906 cites W2009436269 @default.
- W2077154906 cites W2024313037 @default.
- W2077154906 cites W2031296193 @default.
- W2077154906 cites W2033484006 @default.
- W2077154906 cites W2037662802 @default.
- W2077154906 cites W2041746316 @default.
- W2077154906 cites W2045541101 @default.
- W2077154906 cites W2045564624 @default.
- W2077154906 cites W2049352641 @default.
- W2077154906 cites W2053114866 @default.
- W2077154906 cites W2053905513 @default.
- W2077154906 cites W2054977086 @default.
- W2077154906 cites W2062847041 @default.
- W2077154906 cites W2066667699 @default.
- W2077154906 cites W2067600636 @default.
- W2077154906 cites W2073595386 @default.
- W2077154906 cites W2076711806 @default.
- W2077154906 cites W2087523518 @default.
- W2077154906 cites W2087917050 @default.
- W2077154906 cites W2088847440 @default.
- W2077154906 cites W2091158130 @default.
- W2077154906 cites W2094030500 @default.
- W2077154906 cites W2096472983 @default.
- W2077154906 cites W2103906073 @default.
- W2077154906 cites W2110713453 @default.
- W2077154906 cites W2111669682 @default.
- W2077154906 cites W2112418527 @default.
- W2077154906 cites W2113054573 @default.
- W2077154906 cites W2113612251 @default.
- W2077154906 cites W2115335486 @default.
- W2077154906 cites W2118094114 @default.
- W2077154906 cites W2118310760 @default.
- W2077154906 cites W2121296504 @default.
- W2077154906 cites W2124488388 @default.
- W2077154906 cites W2127608249 @default.
- W2077154906 cites W2144379262 @default.
- W2077154906 cites W2149117402 @default.
- W2077154906 cites W2154043420 @default.
- W2077154906 cites W2160427718 @default.
- W2077154906 cites W2477872031 @default.
- W2077154906 cites W2337109902 @default.
- W2077154906 cites W2910997686 @default.
- W2077154906 doi "https://doi.org/10.1159/000210449" @default.
- W2077154906 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2880725" @default.
- W2077154906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19339786" @default.
- W2077154906 hasPublicationYear "2009" @default.
- W2077154906 type Work @default.
- W2077154906 sameAs 2077154906 @default.
- W2077154906 citedByCount "19" @default.
- W2077154906 countsByYear W20771549062012 @default.
- W2077154906 countsByYear W20771549062013 @default.
- W2077154906 countsByYear W20771549062015 @default.
- W2077154906 countsByYear W20771549062017 @default.
- W2077154906 countsByYear W20771549062018 @default.
- W2077154906 countsByYear W20771549062019 @default.
- W2077154906 countsByYear W20771549062021 @default.
- W2077154906 countsByYear W20771549062022 @default.
- W2077154906 crossrefType "journal-article" @default.
- W2077154906 hasAuthorship W2077154906A5004538115 @default.
- W2077154906 hasAuthorship W2077154906A5011126513 @default.
- W2077154906 hasAuthorship W2077154906A5017431021 @default.
- W2077154906 hasAuthorship W2077154906A5017852596 @default.
- W2077154906 hasAuthorship W2077154906A5032497724 @default.
- W2077154906 hasAuthorship W2077154906A5051538332 @default.
- W2077154906 hasAuthorship W2077154906A5062093157 @default.
- W2077154906 hasAuthorship W2077154906A5088012985 @default.
- W2077154906 hasAuthorship W2077154906A5091688246 @default.
- W2077154906 hasBestOaLocation W20771549061 @default.
- W2077154906 hasConcept C104317684 @default.