FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077155118> ?p ?o ?g. }

• W2077155118 endingPage "220" @default.
• W2077155118 startingPage "220" @default.
• W2077155118 abstract "The aim of this study was to analyze the correlation of the expression of MET and cyclin D1 and MET gene copy number in non-small cell lung cancer (NSCLC) tissues and patient clinicopathologic characteristics and sur-vival. Sixty-one NSCLC tissue specimens were included in the study. The expression of MET and cyclin D1 was evaluated by immunohistochemistry and MET gene copy number was assessed by quantitative real-time polymer-ase chain reaction (Q-PCR). Positive expression of MET and cyclin D1 protein and increased MET gene copy number occurred in 59.0%, 59.0% and 18.0% of 61 NSCLC tissues, respectively. MET-positivity correlated with poor differentiation (P = 0.009). Increased MET gene copy number was significantly associated with lymph node metastasis (P = 0.004) and advanced tumor stage (P = 0.048), while the expression of cyclin D1 was not associ-ated with any clinicopathologic parameters. There was a significant correlation between the expression of MET and MET gene copy number (P = 0.002). Additionally, the expression of cyclin D1 had a significant association with the expression of MET as well as MET gene copy number (P = 0.002 and P = 0.017, respectively). MET-positivity and increased MET gene copy number were significantly associated with poor overall survival (P = 0.003 and P < 0.001, respectively) in univariate analysis. Multivariate Cox proportional hazard analysis confirmed that the expression of MET and MET gene copy number were prognostic indicators of NSCLC (P = 0.003 and P = 0.001, respectively). The overexpression of MET and the increased MET gene copy number might be adverse prognostic factors for NSCLC patients. The activation of the MET/cyclin D1 signaling pathway may contribute to carcino-genesis and the development of NSCLC, and may represent a target for therapy." @default.
• W2077155118 created "2016-06-24" @default.
• W2077155118 creator A5033911939 @default.
• W2077155118 creator A5050725115 @default.
• W2077155118 creator A5055084776 @default.
• W2077155118 creator A5064300082 @default.
• W2077155118 creator A5065529048 @default.
• W2077155118 creator A5076849176 @default.
• W2077155118 date "2013-01-01" @default.
• W2077155118 modified "2023-10-12" @default.
• W2077155118 title "Prognostic value of MET, cyclin D1 and MET gene copy number in non-small cell lung cancer" @default.
• W2077155118 cites W1426393029 @default.
• W2077155118 cites W1963592300 @default.
• W2077155118 cites W1969987955 @default.
• W2077155118 cites W1973967612 @default.
• W2077155118 cites W1974918522 @default.
• W2077155118 cites W1988074023 @default.
• W2077155118 cites W1989786382 @default.
• W2077155118 cites W1999740664 @default.
• W2077155118 cites W2010162728 @default.
• W2077155118 cites W2010991568 @default.
• W2077155118 cites W2025288154 @default.
• W2077155118 cites W2026805792 @default.
• W2077155118 cites W2030800943 @default.
• W2077155118 cites W2046498070 @default.
• W2077155118 cites W2052378862 @default.
• W2077155118 cites W2053237036 @default.
• W2077155118 cites W2055080028 @default.
• W2077155118 cites W2055718473 @default.
• W2077155118 cites W2056187710 @default.
• W2077155118 cites W2056837471 @default.
• W2077155118 cites W2057114606 @default.
• W2077155118 cites W2074242691 @default.
• W2077155118 cites W2075081031 @default.
• W2077155118 cites W2077595209 @default.
• W2077155118 cites W2078668548 @default.
• W2077155118 cites W2092508299 @default.
• W2077155118 cites W2093613683 @default.
• W2077155118 cites W2100828885 @default.
• W2077155118 cites W2105333585 @default.
• W2077155118 cites W2121260558 @default.
• W2077155118 cites W2122696117 @default.
• W2077155118 cites W2128955496 @default.
• W2077155118 cites W2136390065 @default.
• W2077155118 cites W2138309116 @default.
• W2077155118 cites W2139641636 @default.
• W2077155118 cites W2154402764 @default.
• W2077155118 cites W2159903328 @default.
• W2077155118 cites W2166097463 @default.
• W2077155118 cites W2320746868 @default.
• W2077155118 cites W2394706731 @default.
• W2077155118 cites W285988926 @default.
• W2077155118 doi "https://doi.org/10.7555/jbr.27.20130004" @default.
• W2077155118 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3664729" @default.
• W2077155118 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23720678" @default.
• W2077155118 hasPublicationYear "2013" @default.
• W2077155118 type Work @default.
• W2077155118 sameAs 2077155118 @default.
• W2077155118 citedByCount "32" @default.
• W2077155118 countsByYear W20771551182013 @default.
• W2077155118 countsByYear W20771551182014 @default.
• W2077155118 countsByYear W20771551182015 @default.
• W2077155118 countsByYear W20771551182016 @default.
• W2077155118 countsByYear W20771551182017 @default.
• W2077155118 countsByYear W20771551182018 @default.
• W2077155118 countsByYear W20771551182019 @default.
• W2077155118 countsByYear W20771551182020 @default.
• W2077155118 countsByYear W20771551182022 @default.
• W2077155118 crossrefType "journal-article" @default.
• W2077155118 hasAuthorship W2077155118A5033911939 @default.
• W2077155118 hasAuthorship W2077155118A5050725115 @default.
• W2077155118 hasAuthorship W2077155118A5055084776 @default.
• W2077155118 hasAuthorship W2077155118A5064300082 @default.
• W2077155118 hasAuthorship W2077155118A5065529048 @default.
• W2077155118 hasAuthorship W2077155118A5076849176 @default.
• W2077155118 hasBestOaLocation W20771551181 @default.
• W2077155118 hasConcept C104317684 @default.
• W2077155118 hasConcept C120821319 @default.
• W2077155118 hasConcept C126322002 @default.
• W2077155118 hasConcept C141231307 @default.
• W2077155118 hasConcept C143998085 @default.
• W2077155118 hasConcept C144301174 @default.
• W2077155118 hasConcept C150194340 @default.
• W2077155118 hasConcept C153911025 @default.
• W2077155118 hasConcept C199835354 @default.
• W2077155118 hasConcept C204232928 @default.
• W2077155118 hasConcept C2776256026 @default.
• W2077155118 hasConcept C2780849966 @default.
• W2077155118 hasConcept C29537977 @default.
• W2077155118 hasConcept C38180746 @default.
• W2077155118 hasConcept C502942594 @default.
• W2077155118 hasConcept C54355233 @default.
• W2077155118 hasConcept C55548728 @default.
• W2077155118 hasConcept C71924100 @default.
• W2077155118 hasConcept C86803240 @default.
• W2077155118 hasConceptScore W2077155118C104317684 @default.
• W2077155118 hasConceptScore W2077155118C120821319 @default.
• W2077155118 hasConceptScore W2077155118C126322002 @default.

• next