FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077155928> ?p ?o ?g. }

• W2077155928 endingPage "1669" @default.
• W2077155928 startingPage "1659" @default.
• W2077155928 abstract "An insertion or deletion (I/D) polymorphism in the angiotensin converting enzyme (ACE) gene and a 4/5-guanine tract polymorphism (4G/5G) in the promoter region of the plasminogen activator inhibitor-1 (PAI-1) gene are associated with the plasma activities of these substances and with coronary heart disease. In smooth muscle cells and mesangial cells, the angiotensin II synthesized by ACE increases mRNA expression and the activity of PAI-1, which promotes antifibrinolysis and the accumulation of extracellular matrix. Therefore, ACE and PAI-1 polymorphisms may have a synergistic effect on diabetic nephropathy and macroangiopathy.Using multivariate logistic regression analyses, we investigated the independent or synergistic effects of the ACE I/D and PAI-1 4G/5G polymorphisms on the development of diabetic nephropathy and macroangiopathy in 208 patients with non-insulin dependent diabetes mellitus (NIDDM) over a 15 year period.Advanced diabetic nephropathy, defined as impaired renal function and diabetic retinopathy, was present in 98 patients. Manifest macrovascular diseases, confirmed by both clinical signs and physical and laboratory examinations, were present in 56 patients. There was no significant difference in the genotype distribution of ACE or PAI-1 polymorphisms between subjects with advanced nephropathy and those with normal renal function. There was no significant difference in the renal survival rate between patients with differing ACE or PAI-1 genotypes. Subjects with macroangiopathy had a higher frequency of the DD genotype than those without macroangiopathy. Subjects with both DD and 4G4G genotypes had a higher incidence of macroangiopathy than those with any other pair of genotypes. Multivariate logistic regression analysis showed that there was no association between ACE or PAI-1 polymorphisms and diabetic nephropathy. The ACE DD genotype and its interaction with the PAI-1 4G4G genotype and the presence of advanced diabetic nephropathy were positively associated with macrovascular disease.These results indicate that the ACE DD genotype and its interaction with the PAI-1 4G4G genotype are independent risk factors for macroangiopathy, but not for the progression of diabetic nephropathy in NIDDM patients, and that the genotyping of PAI-1 and ACE polymorphisms, especially in patients with advanced diabetic nephropathy, may be useful for predicting and preventing macroangiopathy-related events." @default.
• W2077155928 created "2016-06-24" @default.
• W2077155928 creator A5004119000 @default.
• W2077155928 creator A5029970447 @default.
• W2077155928 creator A5046418468 @default.
• W2077155928 creator A5075732053 @default.
• W2077155928 creator A5077410853 @default.
• W2077155928 creator A5081719901 @default.
• W2077155928 date "1998-11-01" @default.
• W2077155928 modified "2023-09-30" @default.
• W2077155928 title "Polymorphisms of angiotensin converting enzyme and plasminogen activator inhibitor-1 genes in diabetes and macroangiopathy" @default.
• W2077155928 cites W1505365469 @default.
• W2077155928 cites W1964524435 @default.
• W2077155928 cites W1965430426 @default.
• W2077155928 cites W1968159865 @default.
• W2077155928 cites W1971370896 @default.
• W2077155928 cites W1972792954 @default.
• W2077155928 cites W1974701948 @default.
• W2077155928 cites W1976005877 @default.
• W2077155928 cites W1977609615 @default.
• W2077155928 cites W1978799672 @default.
• W2077155928 cites W1980000060 @default.
• W2077155928 cites W2000512590 @default.
• W2077155928 cites W2008380110 @default.
• W2077155928 cites W2012749910 @default.
• W2077155928 cites W2012888011 @default.
• W2077155928 cites W2013709047 @default.
• W2077155928 cites W2023362855 @default.
• W2077155928 cites W2035671743 @default.
• W2077155928 cites W2043600435 @default.
• W2077155928 cites W2061415915 @default.
• W2077155928 cites W2068359901 @default.
• W2077155928 cites W2083553445 @default.
• W2077155928 cites W2096810815 @default.
• W2077155928 cites W2097532633 @default.
• W2077155928 cites W2107908226 @default.
• W2077155928 cites W2123173784 @default.
• W2077155928 cites W2134107449 @default.
• W2077155928 cites W2141230518 @default.
• W2077155928 cites W2157675887 @default.
• W2077155928 cites W2287328722 @default.
• W2077155928 cites W2312388685 @default.
• W2077155928 cites W2324579467 @default.
• W2077155928 cites W2329157757 @default.
• W2077155928 cites W2615684303 @default.
• W2077155928 cites W2883545750 @default.
• W2077155928 cites W48031782 @default.
• W2077155928 doi "https://doi.org/10.1046/j.1523-1755.1998.00139.x" @default.
• W2077155928 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9844142" @default.
• W2077155928 hasPublicationYear "1998" @default.
• W2077155928 type Work @default.
• W2077155928 sameAs 2077155928 @default.
• W2077155928 citedByCount "65" @default.
• W2077155928 countsByYear W20771559282012 @default.
• W2077155928 countsByYear W20771559282013 @default.
• W2077155928 countsByYear W20771559282014 @default.
• W2077155928 countsByYear W20771559282015 @default.
• W2077155928 countsByYear W20771559282016 @default.
• W2077155928 countsByYear W20771559282017 @default.
• W2077155928 countsByYear W20771559282018 @default.
• W2077155928 countsByYear W20771559282019 @default.
• W2077155928 countsByYear W20771559282020 @default.
• W2077155928 countsByYear W20771559282021 @default.
• W2077155928 countsByYear W20771559282022 @default.
• W2077155928 crossrefType "journal-article" @default.
• W2077155928 hasAuthorship W2077155928A5004119000 @default.
• W2077155928 hasAuthorship W2077155928A5029970447 @default.
• W2077155928 hasAuthorship W2077155928A5046418468 @default.
• W2077155928 hasAuthorship W2077155928A5075732053 @default.
• W2077155928 hasAuthorship W2077155928A5077410853 @default.
• W2077155928 hasAuthorship W2077155928A5081719901 @default.
• W2077155928 hasBestOaLocation W20771559281 @default.
• W2077155928 hasConcept C104317684 @default.
• W2077155928 hasConcept C126322002 @default.
• W2077155928 hasConcept C134018914 @default.
• W2077155928 hasConcept C135763542 @default.
• W2077155928 hasConcept C159641895 @default.
• W2077155928 hasConcept C27016395 @default.
• W2077155928 hasConcept C2779611605 @default.
• W2077155928 hasConcept C2779679481 @default.
• W2077155928 hasConcept C2779922275 @default.
• W2077155928 hasConcept C2780675426 @default.
• W2077155928 hasConcept C2781184683 @default.
• W2077155928 hasConcept C55493867 @default.
• W2077155928 hasConcept C555293320 @default.
• W2077155928 hasConcept C71924100 @default.
• W2077155928 hasConcept C76252995 @default.
• W2077155928 hasConcept C84393581 @default.
• W2077155928 hasConcept C86803240 @default.
• W2077155928 hasConceptScore W2077155928C104317684 @default.
• W2077155928 hasConceptScore W2077155928C126322002 @default.
• W2077155928 hasConceptScore W2077155928C134018914 @default.
• W2077155928 hasConceptScore W2077155928C135763542 @default.
• W2077155928 hasConceptScore W2077155928C159641895 @default.
• W2077155928 hasConceptScore W2077155928C27016395 @default.
• W2077155928 hasConceptScore W2077155928C2779611605 @default.
• W2077155928 hasConceptScore W2077155928C2779679481 @default.
• W2077155928 hasConceptScore W2077155928C2779922275 @default.

• next