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- W2077156952 abstract "Abstract It has been proposed that choroidal malignant melanoma cells may be disseminated through the systemic circulation at the time of enucleation and lead to metastatic disease. Immobilization of tumor cells by freezing the base of the tumor during enucleation (cryoenucleation) has been suggested, but previous instrumentation has been difficult to apply without freezing surrounding orbital tissues. The Gallie Cryoenucleator insulates adjacent tissues while liquid nitrogen (–196°C) to the sclera. Intraoperative ultrasound assures accurate placement of the Cryoeriucleator under the tumor base and permits the depth of freeze to be monitored. The instrument has been used to facilitate cryoenucleation in 43 eyes containing choroidal malignant melanomas over the past 5 years. Five patients have developed metastatic disease, which became apparent 12 to 42 months post-cryoenucleation. Although it is not known if cryoenucleation does prevent metastasis of choroidal melanoma, the Cryoenucleator provides a simple and safe way to apply this theoretically beneficial technique." @default.
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- W2077156952 date "1984-01-01" @default.
- W2077156952 modified "2023-09-27" @default.
- W2077156952 title "A New Instrument for Cryoenucleation" @default.
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- W2077156952 doi "https://doi.org/10.1016/s0161-6420(84)34387-1" @default.
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