Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077159378> ?p ?o ?g. }
- W2077159378 endingPage "317" @default.
- W2077159378 startingPage "308" @default.
- W2077159378 abstract "Chronic infection with hepatitis C virus (HCV) is a major public health problem, with nearly 170 million infected individuals worldwide. Current treatment for chronic infection is a combination of pegylated IFN-α2 and ribavirin (RBV); however, this treatment is effective in fewer than 50% of patients infected with HCV genotype 1 or 4. Recent studies identified the chemokine CXCL10 (also known as IP-10) as an important negative prognostic biomarker. Given that CXCL10 mediates chemoattraction of activated lymphocytes, it is counterintuitive that this chemokine correlates with therapeutic nonresponsiveness. Herein, we offer new insight into this paradox and provide evidence that CXCL10 in the plasma of patients chronically infected with HCV exists in an antagonist form, due to in situ amino-terminal truncation of the protein. We further demonstrated that dipeptidyl peptidase IV (DPP4; also known as CD26), possibly in combination with other proteases, mediates the generation of the antagonist form(s) of CXCL10. These data offer what we believe to be the first evidence for CXCL10 antagonism in human disease and identify a possible factor contributing to the inability of patients to clear HCV." @default.
- W2077159378 created "2016-06-24" @default.
- W2077159378 creator A5008298910 @default.
- W2077159378 creator A5010848991 @default.
- W2077159378 creator A5012095540 @default.
- W2077159378 creator A5022046936 @default.
- W2077159378 creator A5036412535 @default.
- W2077159378 creator A5037962759 @default.
- W2077159378 creator A5055055641 @default.
- W2077159378 creator A5068647396 @default.
- W2077159378 creator A5076282431 @default.
- W2077159378 creator A5078075662 @default.
- W2077159378 creator A5082652348 @default.
- W2077159378 creator A5084193628 @default.
- W2077159378 date "2011-01-04" @default.
- W2077159378 modified "2023-10-18" @default.
- W2077159378 title "Evidence for an antagonist form of the chemokine CXCL10 in patients chronically infected with HCV" @default.
- W2077159378 cites W1517524419 @default.
- W2077159378 cites W1922988634 @default.
- W2077159378 cites W1965186496 @default.
- W2077159378 cites W1975992923 @default.
- W2077159378 cites W1983606789 @default.
- W2077159378 cites W1985680307 @default.
- W2077159378 cites W1987365816 @default.
- W2077159378 cites W1990985385 @default.
- W2077159378 cites W1997491414 @default.
- W2077159378 cites W1997677874 @default.
- W2077159378 cites W2000409038 @default.
- W2077159378 cites W2001360631 @default.
- W2077159378 cites W2001781773 @default.
- W2077159378 cites W2004866068 @default.
- W2077159378 cites W2006332998 @default.
- W2077159378 cites W2010681459 @default.
- W2077159378 cites W2029323175 @default.
- W2077159378 cites W2030104330 @default.
- W2077159378 cites W2038756414 @default.
- W2077159378 cites W2041186969 @default.
- W2077159378 cites W2052325775 @default.
- W2077159378 cites W2052553326 @default.
- W2077159378 cites W2052572105 @default.
- W2077159378 cites W2056539843 @default.
- W2077159378 cites W2071601558 @default.
- W2077159378 cites W2073293272 @default.
- W2077159378 cites W2074450526 @default.
- W2077159378 cites W2079994168 @default.
- W2077159378 cites W209639396 @default.
- W2077159378 cites W2097224767 @default.
- W2077159378 cites W2100729071 @default.
- W2077159378 cites W2101682111 @default.
- W2077159378 cites W2107749930 @default.
- W2077159378 cites W2111359040 @default.
- W2077159378 cites W2116224427 @default.
- W2077159378 cites W2119544585 @default.
- W2077159378 cites W2125852723 @default.
- W2077159378 cites W2129196237 @default.
- W2077159378 cites W2155093913 @default.
- W2077159378 cites W2171272089 @default.
- W2077159378 cites W313048209 @default.
- W2077159378 cites W4239941293 @default.
- W2077159378 doi "https://doi.org/10.1172/jci40594" @default.
- W2077159378 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3007131" @default.
- W2077159378 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21183794" @default.
- W2077159378 hasPublicationYear "2011" @default.
- W2077159378 type Work @default.
- W2077159378 sameAs 2077159378 @default.
- W2077159378 citedByCount "172" @default.
- W2077159378 countsByYear W20771593782012 @default.
- W2077159378 countsByYear W20771593782013 @default.
- W2077159378 countsByYear W20771593782014 @default.
- W2077159378 countsByYear W20771593782015 @default.
- W2077159378 countsByYear W20771593782016 @default.
- W2077159378 countsByYear W20771593782017 @default.
- W2077159378 countsByYear W20771593782018 @default.
- W2077159378 countsByYear W20771593782019 @default.
- W2077159378 countsByYear W20771593782020 @default.
- W2077159378 countsByYear W20771593782021 @default.
- W2077159378 countsByYear W20771593782022 @default.
- W2077159378 countsByYear W20771593782023 @default.
- W2077159378 crossrefType "journal-article" @default.
- W2077159378 hasAuthorship W2077159378A5008298910 @default.
- W2077159378 hasAuthorship W2077159378A5010848991 @default.
- W2077159378 hasAuthorship W2077159378A5012095540 @default.
- W2077159378 hasAuthorship W2077159378A5022046936 @default.
- W2077159378 hasAuthorship W2077159378A5036412535 @default.
- W2077159378 hasAuthorship W2077159378A5037962759 @default.
- W2077159378 hasAuthorship W2077159378A5055055641 @default.
- W2077159378 hasAuthorship W2077159378A5068647396 @default.
- W2077159378 hasAuthorship W2077159378A5076282431 @default.
- W2077159378 hasAuthorship W2077159378A5078075662 @default.
- W2077159378 hasAuthorship W2077159378A5082652348 @default.
- W2077159378 hasAuthorship W2077159378A5084193628 @default.
- W2077159378 hasBestOaLocation W20771593781 @default.
- W2077159378 hasConcept C126322002 @default.
- W2077159378 hasConcept C13373296 @default.
- W2077159378 hasConcept C134018914 @default.
- W2077159378 hasConcept C156490143 @default.
- W2077159378 hasConcept C159047783 @default.
- W2077159378 hasConcept C170493617 @default.