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- W2077160232 abstract "2 cases of endometrial carcinoma arising in patients with gonadal dysgenesis are reported. A 29-year-old woman originally presenting with menorrhagia was found to have developed Grade 1 adenocarcinoma 5 years later. The patient showed some features of Turner's syndrome, and analysis of blood lymphocytes revealed chromosomal mosaicism. Total hysterectomy and salpingo-oophorectomy were performed, and an extensive adenosquamous tumor was found. The patient has shown no evidence of tumor recurrence for 13 years. A 2nd patient, presenting with menorrhagia at 21 years of age, was found to have focal adenomatous hyperplasia Grade 2 within a year. She was placed on cyclic hormone therapy. 6 years after 1st examination Grade 1 adenocarcinoma with squamous metaplasia was diagnosed and removed by hysterectomy with wedge resection of the ovaries. This patient has also remained well for 7 years after the surgery. Perhaps the development of endometrial carcinoma in these cases, theoretically improbable because of the infantile uteri, is due to the high levels of unopposed endogenous estrogens. In light of this possibility, cyclic estrogen-progestogen therapy might be more appropriate than the traditional estrogen replacement therapy for treatment of cases of gonadal dysgenesis." @default.
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- W2077160232 date "1978-08-01" @default.
- W2077160232 modified "2023-09-27" @default.
- W2077160232 title "Endometrial carcinoma in gonadal dysgenesis with and without estrogen therapy" @default.
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- W2077160232 doi "https://doi.org/10.1016/0090-8258(78)90038-0" @default.
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