Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077161346> ?p ?o ?g. }
- W2077161346 endingPage "1154" @default.
- W2077161346 startingPage "1143" @default.
- W2077161346 abstract "The reactive metabolites of benzo[a]pyrene (B[a]P) and cyclopenta[c,d]pyrene (CPP) induced an accumulation/phosphorylation of p53 in Hepa1c1c7 cells, whereas inhibition of p53 reduced the apoptosis. Judged by the inhibiting effect of wortmannin, phosphatidyl-inositol-3 (PI-3) kinases such as DNA-dependent protein kinase (DNA-PK), ATM (ataxia-telangiectasia mutated), and/or ATR (ATM related kinase), appeared to be involved in the DNA damage recognition and the B[a]P-/CPP-induced accumulation of p53. B[a]P and CPP also induced phosphorylation of jun-N-terminal kinase (JNK) and p38 mitogen activated protein kinase (MAPK). While inhibition of JNK had no effects on the B[a]P-/CPP-induced apoptosis, inhibition of p38 MAPK activity reduced this effect. Interestingly, survival signals such as phosphorylation of Akt and Bad seemed to be induced by the B[a]P-/CPP-compounds. Furthermore, also extracellular signal-regulated kinase (ERK)1/2 was activated and seemed to function as a survival signal in B[a]P-/CPP-induced apoptosis." @default.
- W2077161346 created "2016-06-24" @default.
- W2077161346 creator A5014466291 @default.
- W2077161346 creator A5032352078 @default.
- W2077161346 creator A5083028455 @default.
- W2077161346 date "2004-09-24" @default.
- W2077161346 modified "2023-10-18" @default.
- W2077161346 title "Role of cell signalling involved in induction of apoptosis by benzo[a]pyrene and cyclopenta[c,d]pyrene in Hepa1c1c7 cells" @default.
- W2077161346 cites W17208169 @default.
- W2077161346 cites W190488077 @default.
- W2077161346 cites W1965407474 @default.
- W2077161346 cites W1970983968 @default.
- W2077161346 cites W1974972333 @default.
- W2077161346 cites W1975032153 @default.
- W2077161346 cites W1976445136 @default.
- W2077161346 cites W1984737615 @default.
- W2077161346 cites W2000552194 @default.
- W2077161346 cites W2001805805 @default.
- W2077161346 cites W2003678864 @default.
- W2077161346 cites W2025793548 @default.
- W2077161346 cites W2028886214 @default.
- W2077161346 cites W2032960075 @default.
- W2077161346 cites W2042315470 @default.
- W2077161346 cites W2042561434 @default.
- W2077161346 cites W2044821717 @default.
- W2077161346 cites W2045931107 @default.
- W2077161346 cites W2056009784 @default.
- W2077161346 cites W2058099454 @default.
- W2077161346 cites W2059995799 @default.
- W2077161346 cites W2060195575 @default.
- W2077161346 cites W2060618478 @default.
- W2077161346 cites W2061724992 @default.
- W2077161346 cites W2073924370 @default.
- W2077161346 cites W2078091557 @default.
- W2077161346 cites W2093628776 @default.
- W2077161346 cites W2093746002 @default.
- W2077161346 cites W2097767970 @default.
- W2077161346 cites W2098394839 @default.
- W2077161346 cites W2098664296 @default.
- W2077161346 cites W2099088814 @default.
- W2077161346 cites W2108780052 @default.
- W2077161346 cites W2122071242 @default.
- W2077161346 cites W2142848667 @default.
- W2077161346 cites W2145727462 @default.
- W2077161346 cites W2147114673 @default.
- W2077161346 cites W2147192624 @default.
- W2077161346 cites W2151162565 @default.
- W2077161346 cites W2161090683 @default.
- W2077161346 cites W2161322323 @default.
- W2077161346 cites W2170591014 @default.
- W2077161346 cites W323331451 @default.
- W2077161346 cites W4240724521 @default.
- W2077161346 doi "https://doi.org/10.1002/jcb.20251" @default.
- W2077161346 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15449320" @default.
- W2077161346 hasPublicationYear "2004" @default.
- W2077161346 type Work @default.
- W2077161346 sameAs 2077161346 @default.
- W2077161346 citedByCount "48" @default.
- W2077161346 countsByYear W20771613462012 @default.
- W2077161346 countsByYear W20771613462014 @default.
- W2077161346 countsByYear W20771613462015 @default.
- W2077161346 countsByYear W20771613462016 @default.
- W2077161346 countsByYear W20771613462017 @default.
- W2077161346 countsByYear W20771613462018 @default.
- W2077161346 countsByYear W20771613462019 @default.
- W2077161346 countsByYear W20771613462020 @default.
- W2077161346 countsByYear W20771613462021 @default.
- W2077161346 countsByYear W20771613462022 @default.
- W2077161346 crossrefType "journal-article" @default.
- W2077161346 hasAuthorship W2077161346A5014466291 @default.
- W2077161346 hasAuthorship W2077161346A5032352078 @default.
- W2077161346 hasAuthorship W2077161346A5083028455 @default.
- W2077161346 hasConcept C114246631 @default.
- W2077161346 hasConcept C11960822 @default.
- W2077161346 hasConcept C124160383 @default.
- W2077161346 hasConcept C153911025 @default.
- W2077161346 hasConcept C184235292 @default.
- W2077161346 hasConcept C185592680 @default.
- W2077161346 hasConcept C190283241 @default.
- W2077161346 hasConcept C2777538855 @default.
- W2077161346 hasConcept C2778308172 @default.
- W2077161346 hasConcept C51551487 @default.
- W2077161346 hasConcept C55493867 @default.
- W2077161346 hasConcept C57074206 @default.
- W2077161346 hasConcept C75217442 @default.
- W2077161346 hasConcept C86803240 @default.
- W2077161346 hasConcept C90934575 @default.
- W2077161346 hasConcept C95444343 @default.
- W2077161346 hasConcept C97029542 @default.
- W2077161346 hasConceptScore W2077161346C114246631 @default.
- W2077161346 hasConceptScore W2077161346C11960822 @default.
- W2077161346 hasConceptScore W2077161346C124160383 @default.
- W2077161346 hasConceptScore W2077161346C153911025 @default.
- W2077161346 hasConceptScore W2077161346C184235292 @default.
- W2077161346 hasConceptScore W2077161346C185592680 @default.
- W2077161346 hasConceptScore W2077161346C190283241 @default.
- W2077161346 hasConceptScore W2077161346C2777538855 @default.
- W2077161346 hasConceptScore W2077161346C2778308172 @default.