Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077162024> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W2077162024 abstract "We tested the hypothesis that surfactant replacement would be beneficial in the acid-aspiration model of acute lung injury. HCl (0.1 N, 2 ml/kg) was injected into the trachea of excised rabbit lungs (n = 8). Control lungs (n = 4) had no intervention. All were perfused with Tyrode's solution mixed 1:1 with autologous whole blood at 40 ml/min/kg for 30 min, and then degassed. A modified natural surfactant (Survanta, Ross Laboratories) was then injected into the trachea of four lungs injured with HCl (100 mg/kg at 25 mg/ml). Two quasi-static pressure-volume curves were determined. The mean alveolar pressures at 50, 60, 70, 80, and 90% of TLC were greater in the HCl group than in the control group (p less than 0.05). However, no difference was observed between the control lungs and those that received HCl + Survanta. In 13 anesthetized, paralyzed, and ventilated rabbits, deflation pressure-volume curves were determined from TLC to FRC (measured by helium dilution). Then, 0.1 N HCl (3 ml/kg) was injected into the trachea and, in seven, Survanta was instilled 5 min later. The mean alveolar pressures at 60, 70, 80, and 90% TLC were higher at 15 and 60 min in the HCl group compared with their pre-HCl time point (p less than 0.05). In the HCl + Survanta group, no differences were seen at 15 min, and only slight increased were seen at 60 min. No effect of surfactant replacement on arterial blood gases was observed. HCl aspiration increased recoil in both excised and in vivo lungs, and surfactant replacement with Survanta returned recoil to normal." @default.
- W2077162024 created "2016-06-24" @default.
- W2077162024 creator A5004080024 @default.
- W2077162024 creator A5018104827 @default.
- W2077162024 date "1990-12-01" @default.
- W2077162024 modified "2023-10-14" @default.
- W2077162024 title "Surfactant Replacement Improves Lung Recoil in Rabbit Lungs after Acid Aspiration" @default.
- W2077162024 cites W1973456588 @default.
- W2077162024 cites W2054685150 @default.
- W2077162024 cites W2066789314 @default.
- W2077162024 cites W2079572716 @default.
- W2077162024 cites W2111071070 @default.
- W2077162024 cites W2137061042 @default.
- W2077162024 cites W2169245028 @default.
- W2077162024 cites W2169502257 @default.
- W2077162024 cites W2272372468 @default.
- W2077162024 cites W2324312308 @default.
- W2077162024 cites W2416861133 @default.
- W2077162024 cites W2085002021 @default.
- W2077162024 doi "https://doi.org/10.1164/ajrccm/142.6_pt_1.1279" @default.
- W2077162024 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2252244" @default.
- W2077162024 hasPublicationYear "1990" @default.
- W2077162024 type Work @default.
- W2077162024 sameAs 2077162024 @default.
- W2077162024 citedByCount "40" @default.
- W2077162024 countsByYear W20771620242014 @default.
- W2077162024 countsByYear W20771620242018 @default.
- W2077162024 crossrefType "journal-article" @default.
- W2077162024 hasAuthorship W2077162024A5004080024 @default.
- W2077162024 hasAuthorship W2077162024A5018104827 @default.
- W2077162024 hasConcept C126322002 @default.
- W2077162024 hasConcept C185592680 @default.
- W2077162024 hasConcept C2777714996 @default.
- W2077162024 hasConcept C42219234 @default.
- W2077162024 hasConcept C43617362 @default.
- W2077162024 hasConcept C55493867 @default.
- W2077162024 hasConcept C58226133 @default.
- W2077162024 hasConcept C70289976 @default.
- W2077162024 hasConcept C71924100 @default.
- W2077162024 hasConceptScore W2077162024C126322002 @default.
- W2077162024 hasConceptScore W2077162024C185592680 @default.
- W2077162024 hasConceptScore W2077162024C2777714996 @default.
- W2077162024 hasConceptScore W2077162024C42219234 @default.
- W2077162024 hasConceptScore W2077162024C43617362 @default.
- W2077162024 hasConceptScore W2077162024C55493867 @default.
- W2077162024 hasConceptScore W2077162024C58226133 @default.
- W2077162024 hasConceptScore W2077162024C70289976 @default.
- W2077162024 hasConceptScore W2077162024C71924100 @default.
- W2077162024 hasLocation W20771620241 @default.
- W2077162024 hasLocation W20771620242 @default.
- W2077162024 hasOpenAccess W2077162024 @default.
- W2077162024 hasPrimaryLocation W20771620241 @default.
- W2077162024 hasRelatedWork W1992075331 @default.
- W2077162024 hasRelatedWork W2019086812 @default.
- W2077162024 hasRelatedWork W2035876908 @default.
- W2077162024 hasRelatedWork W2129957162 @default.
- W2077162024 hasRelatedWork W2157180556 @default.
- W2077162024 hasRelatedWork W2328146326 @default.
- W2077162024 hasRelatedWork W2372617185 @default.
- W2077162024 hasRelatedWork W2748952813 @default.
- W2077162024 hasRelatedWork W2899084033 @default.
- W2077162024 hasRelatedWork W2917524362 @default.
- W2077162024 isParatext "false" @default.
- W2077162024 isRetracted "false" @default.
- W2077162024 magId "2077162024" @default.
- W2077162024 workType "article" @default.