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- W2077165247 endingPage "142" @default.
- W2077165247 startingPage "135" @default.
- W2077165247 abstract "Activation of phosphatidylinositol (PI)-kinase is involved in the regulation of a wide array of cellular activities. The enzyme exists as a dimer, consisting of a catalytic and a regulatory subunit. Five isoforms of the regulatory subunit have been identified and classified into three groups comprising respectively 85-kDa, 55-kDa, and 50-kDa proteins. Structural differences in the N-terminal regions of the different group members contribute to defining their binding specificity, their subcellular distributions, and their capacity to activate the 110-kDa catalytic subunit. Two widely distributed isoforms of the catalytic subunit have been identified-p110alpha and p110beta. Despite the fact that they bind to the p85alpha regulatory subunit similarly, p110alpha and p110beta appear to have separate functions within cells and to be activated by different stimuli. Moreover, although p85/p110 PI-kinase almost exclusively phosphorylates the D-3 position of the inositol ring in phosphoinositides when purified PI is used as a substrate in vitro, it appears to phosphorylate the D-4 position with similar or higher efficiency in vivo. Thus, it is highly probable that p85/p110 PI-kinase transmits signals to downstream targets via both D-3- and D-4-phosphorylated phosphoinositides." @default.
- W2077165247 created "2016-06-24" @default.
- W2077165247 creator A5011380065 @default.
- W2077165247 creator A5022721458 @default.
- W2077165247 creator A5038413661 @default.
- W2077165247 creator A5043984865 @default.
- W2077165247 creator A5066087614 @default.
- W2077165247 date "2000-03-01" @default.
- W2077165247 modified "2023-09-30" @default.
- W2077165247 title "Structure and function of phosphatidylinositol-3,4 kinase" @default.
- W2077165247 cites W133456552 @default.
- W2077165247 cites W1493793163 @default.
- W2077165247 cites W1499176799 @default.
- W2077165247 cites W1524794243 @default.
- W2077165247 cites W1526250277 @default.
- W2077165247 cites W1544175192 @default.
- W2077165247 cites W1547466369 @default.
- W2077165247 cites W1550981215 @default.
- W2077165247 cites W1553563097 @default.
- W2077165247 cites W1555224377 @default.
- W2077165247 cites W1566581202 @default.
- W2077165247 cites W1591614032 @default.
- W2077165247 cites W1599492027 @default.
- W2077165247 cites W1601873036 @default.
- W2077165247 cites W1602103287 @default.
- W2077165247 cites W1603755042 @default.
- W2077165247 cites W1607064462 @default.
- W2077165247 cites W1614056212 @default.
- W2077165247 cites W1773423646 @default.
- W2077165247 cites W1838131144 @default.
- W2077165247 cites W1841050729 @default.
- W2077165247 cites W1856121658 @default.
- W2077165247 cites W1920844816 @default.
- W2077165247 cites W1929094692 @default.
- W2077165247 cites W1933600315 @default.
- W2077165247 cites W1965703662 @default.
- W2077165247 cites W1967941200 @default.
- W2077165247 cites W1971377120 @default.
- W2077165247 cites W1973466083 @default.
- W2077165247 cites W1974241409 @default.
- W2077165247 cites W1975573101 @default.
- W2077165247 cites W1975898157 @default.
- W2077165247 cites W1978627586 @default.
- W2077165247 cites W1979187651 @default.
- W2077165247 cites W1985113364 @default.
- W2077165247 cites W1988013831 @default.
- W2077165247 cites W1991276398 @default.
- W2077165247 cites W1992628345 @default.
- W2077165247 cites W1993860552 @default.
- W2077165247 cites W1999824494 @default.
- W2077165247 cites W2000790515 @default.
- W2077165247 cites W2001961027 @default.
- W2077165247 cites W2003324016 @default.
- W2077165247 cites W2004123711 @default.
- W2077165247 cites W2004972894 @default.
- W2077165247 cites W2007012814 @default.
- W2077165247 cites W2008223259 @default.
- W2077165247 cites W2010995825 @default.
- W2077165247 cites W2012438883 @default.
- W2077165247 cites W2012744743 @default.
- W2077165247 cites W2013131355 @default.
- W2077165247 cites W2014186158 @default.
- W2077165247 cites W2016398041 @default.
- W2077165247 cites W2017499074 @default.
- W2077165247 cites W2022122132 @default.
- W2077165247 cites W2022651685 @default.
- W2077165247 cites W2024895303 @default.
- W2077165247 cites W2028634080 @default.
- W2077165247 cites W2029733430 @default.
- W2077165247 cites W2031504013 @default.
- W2077165247 cites W2034024825 @default.
- W2077165247 cites W2034397029 @default.
- W2077165247 cites W2037773563 @default.
- W2077165247 cites W2038792215 @default.
- W2077165247 cites W2038816853 @default.
- W2077165247 cites W2039909459 @default.
- W2077165247 cites W2041102071 @default.
- W2077165247 cites W2044725781 @default.
- W2077165247 cites W2046974658 @default.
- W2077165247 cites W2047081898 @default.
- W2077165247 cites W2051109754 @default.
- W2077165247 cites W2053310263 @default.
- W2077165247 cites W2054154217 @default.
- W2077165247 cites W2054379164 @default.
- W2077165247 cites W2054495952 @default.
- W2077165247 cites W2055405116 @default.
- W2077165247 cites W2057015841 @default.
- W2077165247 cites W2059738943 @default.
- W2077165247 cites W2063975035 @default.
- W2077165247 cites W2067917889 @default.
- W2077165247 cites W2075171680 @default.
- W2077165247 cites W2075339282 @default.
- W2077165247 cites W2076606604 @default.
- W2077165247 cites W2091179088 @default.
- W2077165247 cites W2091349362 @default.
- W2077165247 cites W2093082265 @default.
- W2077165247 cites W2099000660 @default.
- W2077165247 cites W2099661341 @default.