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• W2077166822 abstract "Extensive research over the past half century has shown that curcumin (diferuloylmethane), a component of the golden spice turmeric (Curcuma longa), can modulate multiple cell signaling pathways. Extensive clinical trials over the past quarter century have addressed the pharmacokinetics, safety, and efficacy of this nutraceutical against numerous diseases in humans. Some promising effects have been observed in patients with various pro-inflammatory diseases including cancer, cardiovascular disease, arthritis, uveitis, ulcerative proctitis, Crohn's disease, ulcerative colitis, irritable bowel disease, tropical pancreatitis, peptic ulcer, gastric ulcer, idiopathic orbital inflammatory pseudotumor, oral lichen planus, gastric inflammation, vitiligo, psoriasis, acute coronary syndrome, atherosclerosis, diabetes, diabetic nephropathy, diabetic microangiopathy, lupus nephritis, renal conditions, acquired immunodeficiency syndrome, β-thalassemia, biliary dyskinesia, Dejerine-Sottas disease, cholecystitis, and chronic bacterial prostatitis. Curcumin has also shown protection against hepatic conditions, chronic arsenic exposure, and alcohol intoxication. Dose-escalating studies have indicated the safety of curcumin at doses as high as 12 g/day over 3 months. Curcumin's pleiotropic activities emanate from its ability to modulate numerous signaling molecules such as pro-inflammatory cytokines, apoptotic proteins, NF-κB, cyclooxygenase-2, 5-LOX, STAT3, C-reactive protein, prostaglandin E(2), prostate-specific antigen, adhesion molecules, phosphorylase kinase, transforming growth factor-β, triglyceride, ET-1, creatinine, HO-1, AST, and ALT in human participants. In clinical trials, curcumin has been used either alone or in combination with other agents. Various formulations of curcumin, including nanoparticles, liposomal encapsulation, emulsions, capsules, tablets, and powder, have been examined. In this review, we discuss in detail the various human diseases in which the effect of curcumin has been investigated." @default.
• W2077166822 created "2016-06-24" @default.
• W2077166822 creator A5032514627 @default.
• W2077166822 creator A5048675624 @default.
• W2077166822 creator A5063325189 @default.
• W2077166822 date "2012-11-10" @default.
• W2077166822 modified "2023-10-16" @default.
• W2077166822 title "Therapeutic Roles of Curcumin: Lessons Learned from Clinical Trials" @default.
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• W2077166822 doi "https://doi.org/10.1208/s12248-012-9432-8" @default.
• W2077166822 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3535097" @default.
• W2077166822 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23143785" @default.
• W2077166822 hasPublicationYear "2012" @default.
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